Figure 9: Thermal unfolding of extremophilic proteins. Thermograms of α-amylases and DNA-ligases recorded by differential scanning microcalorimetry showing, from left to right on each panel, psychrophilic (blue), mesophilic (black), and (hyper)thermophilic (red) proteins. The cold-adapted proteins are characterized by a lower (top of the transition) and (area under the transition), by a sharp and cooperative transition and by the lack of stability domains (indicated by thin lines in stable proteins). Adapted from [158, 189].