Table 2: Causes of nonadherence.

Factors linked to the patient(i) Presence of physical disorders
(ii) Cognitive difficulties
(iii) Psychiatric comorbidities
(iv) Age (children, adolescents, and elderly present high risk of nonadherence)
(v) Knowledge
(vi) Expectations
(vii) Social and family support
(viii) Coping style

Variables linked to the disease (i) Chronicity
(ii) Symptom stability
(iii) Absence of symptoms

Variables linked to the treatment(i) High number of daily doses
(ii) Presence of side effects
(iii) Complexity of the therapeutic regimes
(iv) Ease of use
(v) Costs

Variables related to the doctor-patient relationship(i) Bad relationship
(ii) Inappropriate doctor or patient behaviour