Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy: The Underlying Mechanisms and Clinical Management
Figure 7
Magnetic resonance images of the brain demonstrating ipilimumab-associated hypophysitis. (a) Prior to therapy, with no metastatic disease indicated. (b) Diffuse enlargement of the pituitary gland following reports of cognitive impairment during therapy. (c) Resolution of hypophysitis after discontinuation of ipilimumab and initiation of hormone-replacement therapy [14]; reproduced with permission from Carpenter et al. 2009 [14].
