Development of the Rat Model of Lapatinib-Induced Diarrhoea

Figure 2

Diarrhoea incidence and severity. Data shown is proportion of rats that experienced diarrhoea at each severity level measured over the duration of treatment, 𝑛=30. Addition of paclitaxel to lapatinib treatment caused a significant increase in the proportion of rats that experienced severe grade diarrhoea (𝑃<0.001, chi-square test).