Utilizing Cytokines to Function-Enable Human NK Cells for the Immunotherapy of Cancer

Table 1

Cytokine receptors on human NK cells.

Receptor	Components	NK subset	Signaling	Functions	Source
IL-2R	IL-2R𝛼; IL-2/15R𝛽; 𝛾c	IL-2R𝛼𝛽𝛾: CD56^bright; IL-2R𝛽𝛾: CD56^bright and CD56^dim	Jak1/3, STAT3/5; PI3K; Ras/Raf/MAPK	Cytokine production; Proliferation; Survival; Enhanced cytotoxicity	T cell
IL-12R	IL-12Rb1; IL-12Rb2	CD56^bright and CD56^dim	Jak2/Tyk2 and; STAT4	Cytokine production; Enhanced cytotoxicity	DC; M𝜑
IL-15R	IL-15R𝛼; IL-2/15R𝛽; 𝛾c	CD56^bright and CD56^dim	Jak1/3 and STAT3/5; PI3K; Ras/Raf/MAPK	Cytokine production; Proliferation; Survival; Enhanced cytotoxicity	DC; M𝜑; BM stroma
IL-18R	IL-18R𝛼/R1; IL-18R𝛽/RAP	CD56^bright and CD56^dim	MyD88, IRAK4/TRAF6,; MAPK, and NFkB	Cytokine production; Proliferation	DC; M𝜑
IL-21R	IL-21R; 𝛾c	CD56^bright and CD56^dim	Jak1/3 and STAT1/3/5	Enhanced cytotoxicity; Enhanced ADCC; Cytokine production; Limits proliferation	T cell