Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human  Lung Cancer Cells

<table>Proposed model of nicotine/NNK signaling in human lung cancer cells. Nicotine or NNK stimulates phosphorylation of Bcl2, Mcl-1, Bad, and Bax via activation of multiple protein kinases leading to activation of Bcl2/Mcl-1, inactivation of Bad/Bax, and promotion of functional cooperation between Bcl2 and c-Myc, which contributes to the survival and proliferation of human lung cancer cells.</table>

Scientifica

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Figure 1

Figure 1: Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human  Lung Cancer Cells 