Review Article

Update on Abdominal Aortic Aneurysm Research: From Clinical to Genetic Studies

Figure 5

A Network of miRNAs, miR-133a, miR-133b, miR-331-3p, and miR-204, and their target genes. Each miRNA is predicted to regulate a large number of target genes (mRNAs). Bioinformatic analysis predicted that 222 genes with upregulated expression in AAA based on a prior microarray study [81] were targets of miR-133a, miR-133b, miR-331, or miR-204. The predicted minimum free energy of the miRNA and target mRNA hybridization from the program RNAhybrid version 2.1.is shown by the line and node color. Black lines for YTHFD3 indicate that the 3′UTR sequence was not available from Ensembl BioMart, and the minimum free energy was not calculated. miR-30c-2* was not included because it is a miRNA* strand that is usually degraded and therefore nonfunctional. The figure is reproduced from [84].
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