Gender Differences in Pulmonary Function, Respiratory Symptoms, and Macrophage Proteomics among HIV-Infected Smokers
Table 5
Proteins that had at least a 2-fold higher expression in alveolar macrophages from women.
Spot number
Mean of normalized volume of male
Mean of normalized volume of female
Fold changes (female/male)
Accession number (Swiss-Prot)
Protein ID
Mowse score
Observed pI/Mr (KDr)
Number of peptides by MS/MS
Total seq. coverage (%)
778
0.0317
0.1257
3.97
P19971
Thymidine phosphorylase
326
5.2/55.0
8
31
947
0.4037
0.9677
2.40
O14773
Tripeptidyl-peptidase I
427
5.7/47.6
3
19
1526
0.0402
0.0855
2.13
P07355
Annexin A2
422
7.6/38.6
6
36
2342
0.0182
0.0443
2.44
Q16781
Ubiquitin-conjugating enzyme E2 N
134
5.7/15.7
2
22
2536
0.0575
0.1312
2.28
P01884
Beta-2-microglobulin
107
6.0/12.0
2
34
4917
0.2527
1.0122
4.01
CAA23759
Unnamed protein product
1004
7.0/13.6
2
95
4947
0.0657
0.1440
2.19
NP_004842
Napsin A preproprotein
1678
5.3/35.0
3
22
8844
0.0028
0.0513
18.12
Q02818
Nucleobindin-1
282
5.2/53.8
11
29
9158
0.0893
0.1852
2.07
1JHW_A
Chain A, Ca2+-binding mimicry in the crystal structure of the Eu3+-bound mutant human macrophage capping protein cap G
1063
4.9/26.3
5
34
9207
0.0112
0.0510
4.57
P07203
Glutathione peroxidase
320
5.5/24.2
4
54
9501
0.0447
0.0922
2.06
P43686-2
Proteasome 26S ATPase subunit 4 isoform 2
192
5.0/62.7
3
18
9629
0.0725
0.2178
3.00
P07237
Protein disulfide-isomerase
937
4.8/57.1
8
34
9658
0.0245
0.1052
4.29
P26038
Moesin
539
6.1/67.9
6
13
Only identified proteins are shown. Accession number: international database of the name and ID number of protein. Fold change: average density of the specific protein in males compared to females. Mowse score: measures reliability of the protein identification; greater than 100 ensures higher reliability that the protein identified is correct. Observed pI/Mr: isoelectric point and molecular weight of the protein. Ms/Ms: number of peptides sequenced after digestion. Total sequence coverage: percentage of the peptide sequenced.
