Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2014, Article ID 724653, 4 pages
http://dx.doi.org/10.1155/2014/724653
Research Article

The Association of −330 Interleukin-2 Gene Polymorphism with Its Plasma Concentration in Iranian Multiple Sclerosis Patients

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, Iran

Received 4 February 2014; Accepted 5 May 2014; Published 19 May 2014

Academic Editor: Pasquale Annunziata

Copyright © 2014 Arezou Sayad and Abolfazl Movafagh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. R. Oksenberg and L. F. Barcellos, “Multiple sclerosis genetics: leaving no stone unturned,” Genes and Immunity, vol. 6, no. 5, pp. 375–387, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. T. R. Malek and A. L. Bayer, “Tolerance, not immunity, crucially depends on IL-2,” Nature Reviews Immunology, vol. 4, no. 9, pp. 665–674, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. T. R. Malek, “The biology of interleukin-2,” Annual Review of Immunology, vol. 26, pp. 453–479, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. C.-Z. Lu, S. Fredrikson, B.-G. Xiao, and H. Link, “Interleukin-2 secreting cells in multiple sclerosis and controls,” Journal of the Neurological Sciences, vol. 120, no. 1, pp. 99–106, 1993. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Gallo, M. Piccinno, S. Pagni, and B. Tavolato, “Interleukin-2 levels in serum and cerebrospinal fluid of multiple sclerosis patients,” Annals of Neurology, vol. 24, no. 6, pp. 795–797, 1988. View at Google Scholar · View at Scopus
  6. P. Gallo, M. G. Piccinno, S. Pagni et al., “Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid,” Journal of the Neurological Sciences, vol. 92, no. 1, pp. 9–15, 1989. View at Google Scholar · View at Scopus
  7. J. L. Trotter, D. B. Clifford, J. E. McInnis et al., “Correlation of immunological studies and disease progression in chronic progressive multiple sclerosis,” Annals of Neurology, vol. 25, no. 2, pp. 172–178, 1989. View at Google Scholar · View at Scopus
  8. J. Reboul, C. Mertens, F. Levillayer et al., “Cytokines in genetic susceptibility to multiple sclerosis: a candidate gene approach,” Journal of Neuroimmunology, vol. 102, no. 1, pp. 107–112, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Matesanz, M. Fedetz, M. Collado-Romero et al., “Allelic expression and interleukin-2 polymorphisms in multiple sclerosis,” Journal of Neuroimmunology, vol. 119, no. 1, pp. 101–105, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. F. Matesanz, M. Fedetz, L. Leyva, C. Delgado, O. Fernández, and A. Alcina, “Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression,” Journal of Neuroimmunology, vol. 148, no. 1-2, pp. 212–217, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Petitto, W. J. Streit, Z. Huang, E. Butfiloski, and J. Schiffenbauer, “Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice,” Neuroscience Letters, vol. 285, no. 1, pp. 66–70, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. S. John, D. Turner, R. Donn et al., “Two novel biallelic polymorphisms in the IL-2 gene,” European Journal of Immunogenetics, vol. 25, no. 6, pp. 419–420, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Sayad, A. Allameh, A. Sayad, M. Noruzinia, and A. Sarzaeem, “The influence of -330 IL-2 gene polymorphism on relapsing remitting and secondary progressive course multiple sclerosis in Iranian patients,” Neurology of Asia Neurology Asia, vol. 18, no. 1, pp. 83–86, 2013. View at Google Scholar
  14. A. Sayad, A. Allameh, A. Sayad et al., “The association of -475 and -631 interleukin-2 gene polymorphism with multiple sclerosis in Iranian patients,” Cell Journal, vol. 15, no. 2, pp. 124–129, 2013. View at Google Scholar
  15. A. Hajifathali, A. Sayad, A. Sayad et al., “The association of -308 TNFα polymorphism and multiple sclerosis in Iranian patients,” CNB Journals, vol. 1, no. 2, pp. 114–121, 2012. View at Google Scholar
  16. A. Sayad, M. T. Akbari, M. Pajouhi, F. Mostafavi, and M. Zamani, “The influence of the HLA-DRB, DQB and polymorphic positions of the HLA-DRβ1 and HLA-DQβ1 molecules on risk of Iranian type 1 diabetes mellitus patients,” International Journal of Immunogenetics, vol. 39, pp. 429–436, 2012. View at Google Scholar
  17. A. Sayad, M. T. Akbari, M. Pajouhi, F. Mostafavi, A. Kazemnejad, and M. Zamani, “The role of the gender on the HLA-DRB1 and DQB1 association with type 1 diabetes mellitus in Iranian patients,” Cell Journal, vol. 15, no. 2, pp. 108–115, 2013. View at Google Scholar
  18. W. I. McDonald, A. Compston, G. Edan et al., “Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis,” Annals of Neurology, vol. 50, no. 1, pp. 121–127, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. S. A. Miller, D. D. Dykes, and H. F. Polesky, “A simple salting out procedure for extracting DNA from human nucleated cells,” Nucleic Acids Research, vol. 16, no. 3, p. 1215, 1988. View at Publisher · View at Google Scholar · View at Scopus
  20. S. C. Hoffmann, E. M. Stanley, E. Darrin Cox et al., “Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes,” Transplantation, vol. 72, no. 8, pp. 1444–1450, 2001. View at Google Scholar · View at Scopus