Figure 6: (a) Schematic of template-directed combinatorial strategy to identify MTX-PNA conjugates. MTX analogs containing a linker-azide combined bipartite PNA with a linker-alkyne in the presence of tau RNA oligonucleotide representing the stem-loop and flanking sequences. MTX and PNA analogs that bind well, with the proper distance and orientation between azide and alkyne, undergo cyclization to a 1,2,3-triazole. (b) MTX conjugated to bipartite PNA identified through template-directed combinatorial chemistry.