TY - JOUR A2 - Ward, Diane AU - Zhao, Bing AU - Chen, Ye-Guang PY - 2014 DA - 2014/09/23 TI - Regulation of TGF-β Signal Transduction SP - 874065 VL - 2014 AB - Transforming growth factor-β (TGF-β) signaling regulates diverse cellular processes, including cell proliferation, differentiation, apoptosis, cell plasticity, and migration. TGF-β signaling can be mediated by Smad proteins or other signaling proteins such as MAP kinases and Akt. TGF-β signaling is tightly regulated at different levels along the pathways to ensure its proper physiological functions in different cells and tissues. Deregulation of TGF-β signaling has been associated with various kinds of diseases, such as cancer and tissue fibrosis. This paper focuses on our recent work on regulation of TGF-β signaling. SN - null UR - https://doi.org/10.1155/2014/874065 DO - 10.1155/2014/874065 JF - Scientifica PB - Hindawi Publishing Corporation KW - ER -