XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis

Figure 1

XB130 functional domains and motifs. The N-terminus of XB130 contains a proline-rich SH3 domain binding motif at aa 98–107 and three tyrosine containing SH2 domain binding sites at aa 54–57, aa 124–127, and aa 148–15. The first SH2 domain binding site contains a YXXM motif that binds the SH2 domain in the p85α subunit of PI3K. In the middle region, there are two PH domains and another SH2 domain binding site at aa 457–460. The C-terminus contains a coiled-coil region.