Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">CCL17<sup>+</sup> DCs</td><td align="left">CD4<sup>+</sup> T-cell recruitment to atherosclerotic lesions <br/>Interference with Treg homeostasis <br/>Not exclusively mediated via CCR4; involvement of other receptors?</td></tr><tr><td align="left" colspan="2"><hr/></td></tr><tr><td align="left">pDCs</td><td align="left">oxLDL induces enhanced T-cell activation capacities<br/>Recognition of self-DNA (complexed to antimicrobial peptide Cramp)<br/>IFN<i>α</i> production, contribution to anti-dsDNA antibody generation</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Atherogenic CCL17<sup>+</sup> DC and pDC functions in a nutshell.

Scientifica

tab1

Table 1

Table 1: Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead 