Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead
Table 1
Atherogenic CCL17+ DC and pDC functions in a nutshell.
CCL17+ DCs
CD4+ T-cell recruitment to atherosclerotic lesions Interference with Treg homeostasis Not exclusively mediated via CCR4; involvement of other receptors?
pDCs
oxLDL induces enhanced T-cell activation capacities Recognition of self-DNA (complexed to antimicrobial peptide Cramp) IFNα production, contribution to anti-dsDNA antibody generation