Scientifica / 2016 / Article / Tab 1

Review Article

The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25

Table 1

The role of the three paralogous miRNA clusters in development and disease.

MicroRNA clusterChromosomeMicroRNAsBiological functionsOncogenic role

miR-17-9213miR-17, miR-18a, miR-19a, miR-19b-1, miR-20a, and miR-92a-1Angiogenesis [51, 104]
Apoptosis [47, 105, 106]
B cell development [38, 42, 107]
Cell cycle progression [47, 105, 106]
Development of lung, heart, kidney, cerebral
hemisphere, small intestine, submandibular
salivary gland, and tooth germ [41, 42, 108]
Enhanced proliferation [42, 44, 85]
Inhibited differentiation [59]
Expression in human:
Colon cancers ↑ [56]
Lung cancers ↑ [44, 59]
Lymphomas ↑ [47]
Solid tumors ↑ [40]
Thyroid cancers ↑ [109, 110]
Tumor angiogenesis [51, 104]

miR-106a-363XmiR-106a, miR-18b, miR-19b-2, miR-20b, miR-92a-2, and miR-363Aging [111]
Angiogenesis [78]
Apoptosis [112]
Cellular growth [79, 85]
Development of lung and heart [84]
Expression in human:
Ewing sarcoma tumors ↓ [113]
Head and neck cancers ↓ [75]
Oral cancers ↓ [85]
T cell leukemia ↑ [32]

miR-106b-257miR-106b, miR-93, and miR-25Apoptosis [87]
Cell cycle progression [32]
Proliferation and differentiation [94]
Expression in human:
Esophageal cancers ↑ [89]
Gastric cancers ↑ [87]
Hepatocellular tumors ↑ [88]
Prostate cancers ↑ [32]

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