Histomorphological and Immunohistochemical Reappraisal of Cutaneous Adnexal Tumours: A Hospital Based Study

Table 6

Salient histopathological features of eccrine and apocrine tumours.

Malignant mixed tumour	(i) Composed of epithelial and chondromyxoid mesenchymal components.; (ii) Epithelial tumour aggregates seen as confluent cords and nests with interspersed zones of tubule formation.; (iii) Numerous mitotic figures and zones of necrosis seen.
Mucinous carcinoma	(i) The tumour cells in numerous compartment divided by strands of fibrous tissue.; (ii) In each compartment, abundant amount of pale staining mucin seen around the nests of anaplastic epithelial cells.; (iii) Some showing tubular lumen and focal duct formations.
Paget disease of breast	(i) Epidermis with scattered Paget cells seen which were large, rounded cells devoid of intercellular bridges containing a large nucleus with ample cytoplasm.; (ii) The dermis showing moderately severe chronic inflammatory reactions.
Syringoma	(i) Numerous small ducts embedded in a fibrous stroma.; (ii) Few ducts that had small, comma-like tails of epithelial cells giving appearance of tadpoles.; (iii) Solid strands of basophilic epithelial cells independent of ducts also seen.
Poroma	(i) Tumour consisting of broad, anastomosing bands from epidermis.; (ii) Tumour cells which are small, cuboidal, and basophilic.; (iii) Cystic spaces lined by eosinophilic PAS positive, diastase resistant cuticle.
Hidradenoma	(i) Multiple lobules of lesional cells.; (ii) Tumour comprised of clear and polygonal cells.; (iii) Foci of eosinophilic material and small preductal lumina seen.; (iv) Focal cystic changes.
Syringocystadenoma papilliferum	(i) Tumour comprised of numerous papillary projections.; (ii) Papillary projections lined by two rows of cells-luminal row-columnar cells with active decapitation secretion, outer row-cuboidal cells.; (iii) The secretions seen as cystic invaginations extending into the dermis.
Eccrine spiradenoma	(i) Well circumscribed aggregates of tumour cells seen in dermis.; (ii) Two types of cells, at the periphery, cells with small dark nuclei, and in the center, large cells with pale nuclei.; (iii) Eosinophilic material in the lumina.