Bubaline Cholecyst Derived Extracellular Matrix for Reconstruction of Full Thickness Skin Wounds in Rats

Table 5

Histopathological scores of various treatment groups at different time intervals.

Parameters	Group I (c)						Group II (b-CS)						Group III (b-CEM)
	Days
	3	7	14	21	28	45	3	7	14	21	28	45	3	7	14	21	28	45
Surface epithelium	4	4	3	2	2	2	3	2	2	2	2	1	3	2	2	2	1	1
Thickness of epithelium	1	2	4	3	2	1	2	4	4	4	3	1	2	4	3	2	2	1
Granulation tissue width	2	4	3	3	2	1	3	3	3	2	1	1	3	3	3	1	1	1
Inflammation	3	2	2	1	1	1	2	1	2	1	1	1	2	1	1	2	1	1
Fibroblast proliferation	2	4	3	4	2	1	4	3	4	3	2	1	4	4	3	2	2	1
Neovascularization	2	4	3	3	2	1	3	3	3	2	1	1	3	3	3	1	1	1
Collagen fiber density	3	3	3	2	1	1	3	2	2	2	1	1	3	1	2	1	1	1
Collagen fiber thickness	3	3	3	3	2	2	3	3	3	3	2	2	3	2	2	1	1	1
Collagen fiber arrangement	4	4	4	2	4	3	3	3	3	3	3	2	3	2	2	2	2	1
Total score	27	30	28	23	18	13	26	24	26	22	16	11	26	22	21	14	12	9

Surface epithelium: 1—complete, 2—incomplete, 3—initialization, and 4—absent.
Thickness of surface epithelium: 1—resembling normal skin, 2—slightly thick, 3—moderately thick, and 4—thicker than normal skin.
Granulation tissue width: 1—narrow, 2—slightly wide, 3—moderately wide, and 4—wide.
Inflammation: 1—absent, 2—mild, 3—moderate, and 4—severe.
Fibroblast proliferation: 1—resembling normal skin, 2—mild, 3—moderate, and 4—severe.
Neovascularization: 1—resembling normal skin, 2—mild, 3—moderate, and 4—severe.
Collagen fiber density: 1—denser, 2—dense, and 3—less dense.
Collagen fiber thickness: 1—thicker, 2—thick, and 3—thin.
Collagen fiber arrangement: 1—best, 2—better, 3—worse, and 4—worst.