Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidone in Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments

Table 3

(a) Normalized square values for acid degradation. (b) Normalized square values for alkali degradation.

(a)

Rank	Expt. number	Value ()		Normalized square
1	(3) ()	20.5	420.25	79.32
2	(5) ()	9	81	15.29
3	(7) ()	5	25	4.71
4	(6) ()	1	1	0.19
5	(8) ()	0	0	0
6	(4) ()	−0.5	0.25	0.57
7	(2) ()	−1.5	2.25	0.42
8	(8) ()	—	—	—
		Total	529.75

(b)

Rank	Expt. number	Value ()		Normalized square
1	(3) ()	21.5	462.25	96.52
2	(5) ()	3	9	1.87
3	(2) ()	2	4	0.84
4	(4) ()	1.5	2.25	0.47
5	(7) ()	0.75	0.5625	0.12
6	(8) ()	0.75	0.5625	0.12
7	(6) ()	−0.5	0.25	0.05
8	(1) ()	—	—	—
		Total	4748.88