Gentamicin Induced Nephrotoxicity: The Role of Sex Hormones in Gonadectomized Male and Female Rats

Table 1

The design of experimental groups.

Gender	Group	Group’s name		Treatment
Female	1	Control	6	Sesame oil + saline
	2	GM	5	Sesame oil + GM
	3	ES 0.25 + GM	5	0.25 mg/kg/week ES in sesame oil + GM
	4	ES 0.5 + GM	5	0.5 mg/kg/week ES in sesame oil + GM
	5	ES 1 + GM	6	1 mg/kg/week ES in sesame oil + GM
	6	Pro + GM	6	10 mg/kg/week Pro in sesame oil + GM
	7	Pro + ES 0.25 + GM	6	(0.25 mg/kg/week ES + 10 mg/kg/week Pro) in sesame oil + GM
	8	Pro + ES 0.5 + GM	7	(0.5 mg/kg/week ES + 10 mg/kg/week Pro) in sesame oil + GM
	9	Pro + ES 1 + GM	6	(1 mg/kg/week ES + 10 mg/kg/week Pro) in sesame oil + GM
Male	10	Control	4	Sesame oil + saline
	11	GM	5	Sesame oil + GM
	12	TS 10 + GM	4	10 mg/kg/week TS in sesame oil + GM
	13	TS 50 + GM	4	50 mg/kg/week TS in sesame oil + GM
	14	TS 100 + GM	5	100 mg/kg/week TS in sesame oil + GM
	15	ES 0.25 + GM	5	0.25 mg/kg/week ES in sesame oil + GM

GM: gentamicin, ES: estradiol, Pro: progesterone, TS: testosterone, and : number of animals.