TY - JOUR
A2 - Osna, Natalia
AU - Venugopal, Vishnu
AU - Kumaran, Ajeeshkumar Kizhakkepurath
AU - Sekhar Chatterjee, Niladri
AU - Kumar, Suvanish
AU - Kavilakath, Shyni
AU - Nair, Jayarani Ramachandran
AU - Mathew, Suseela
PY - 2016
DA - 2016/05/31
TI - Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y)
SP - 6294030
VL - 2016
AB - The objective of the present study was to characterize the liver oil extracted from the deep sea shark, Echinorhinus brucus, caught from Central Indian Ocean and to evaluate its cytotoxic effect on neuroblastoma cell line (SHSY-5Y). Characterization of liver oil of Echinorhinus brucus revealed the presence of palmitic acid (15%), oleic acid (12%), stearic acid (8%), docosahexaenoic acid (DHA) (18%), and eicosapentaenoic acid (EPA) (16%). It was also found to be a good source of squalene (38.5%) and fat soluble vitamins such as A, D, and K (vitamin A: 17.08 mg/100 g of oil, vitamin D: 15.04 mg/100 g oil, and vitamin K: 11.45 mg/100 g oil). Since it was found to be rich in essential fatty acids, fat soluble vitamins, and squalene, it can be considered as better dietary supplement. The oil of Echinorhinus brucus also showed high in vitro cytotoxic effect against the human neuroblastoma cell line (SHSY-5Y) and the IC50 value laid between 35 and 45 ng.
SN - null
UR - https://doi.org/10.1155/2016/6294030
DO - 10.1155/2016/6294030
JF - Scientifica
PB - Hindawi Publishing Corporation
KW -
ER -