TY - JOUR A2 - Osna, Natalia AU - Venugopal, Vishnu AU - Kumaran, Ajeeshkumar Kizhakkepurath AU - Sekhar Chatterjee, Niladri AU - Kumar, Suvanish AU - Kavilakath, Shyni AU - Nair, Jayarani Ramachandran AU - Mathew, Suseela PY - 2016 DA - 2016/05/31 TI - Biochemical Characterization of Liver Oil of Echinorhinus brucus (Bramble Shark) and Its Cytotoxic Evaluation on Neuroblastoma Cell Lines (SHSY-5Y) SP - 6294030 VL - 2016 AB - The objective of the present study was to characterize the liver oil extracted from the deep sea shark, Echinorhinus brucus, caught from Central Indian Ocean and to evaluate its cytotoxic effect on neuroblastoma cell line (SHSY-5Y). Characterization of liver oil of Echinorhinus brucus revealed the presence of palmitic acid (15%), oleic acid (12%), stearic acid (8%), docosahexaenoic acid (DHA) (18%), and eicosapentaenoic acid (EPA) (16%). It was also found to be a good source of squalene (38.5%) and fat soluble vitamins such as A, D, and K (vitamin A: 17.08 mg/100 g of oil, vitamin D: 15.04 mg/100 g oil, and vitamin K: 11.45 mg/100 g oil). Since it was found to be rich in essential fatty acids, fat soluble vitamins, and squalene, it can be considered as better dietary supplement. The oil of Echinorhinus brucus also showed high in vitro cytotoxic effect against the human neuroblastoma cell line (SHSY-5Y) and the IC50 value laid between 35 and 45 ng. SN - null UR - https://doi.org/10.1155/2016/6294030 DO - 10.1155/2016/6294030 JF - Scientifica PB - Hindawi Publishing Corporation KW - ER -