Virulent Properties of Russian Bovine Viral Diarrhea Virus Strains in Experimentally Infected Calves

Table 2

Pathogenic properties of bovine viral diarrhea virus (BVDV) cytopathic strains of type 1 after aerosol challenge of 4–6-month-old calves with the dose of 6 log₁₀ TCD₅₀.

Name of the strain/isolation source	Subtype	Manifestation form of the disease	Time of leukopenia (days postinfection), the lowest concentration of leukocytes (cells/mm^3, for )	Presence of antibodies to BVDV	Type of organ system with BVDV genome
B1/calf lung	1b	Acute (acute respiratory infection, diarrhea)	3–10, 2800 ± 400	+	Lymphoid (spleen, pulmonary lymph nodes), respiratory (lungs), and intestinal (small intestine, duodenum, ileum, and mesenteric lymph nodes)
T1/calf lung	1b	Acute (acute respiratory infection, diarrhea)	4–9, 3800 ± 400	±	Lymphoid (spleen, mesenteric lymph nodes, Peyer’s patches, and mesenteric lymph nodes)

, mean value.
, 95% confidence interval.
, number of animals.
The value is below that for T1 strain according to the Mann-Whitney test and Student’s -test at .