Spina Bifida: Pathogenesis, Mechanisms, and Genes in Mice and Humans

Table 5

Neural tube structure	Genes expressed at
	Neuroepithelium; Zic2 [104]; Vangl2 [105]
	Floor plate and notochord; HNF3 [106]; Vangl1 [107]; Wnt3a [108]; Cyp26a1 [8, 109]; Shh [11]; Map3k4 [110]; Marcksl1 (Mlp) [18, 111]; Traf4 [21, 95]
	Notochord; BMP7 [112]; Brachyury [6]; Shh [10, 11, 113, 114]
	Surface ectoderm; Fgf8 [115]; Grainyhead-like 2 [116]; BMP7 [104]; Wnt6 [104]; Notch1 [108]
	Dorsolateral hinge points; None
	Tips of neural folds at E9.5; Axin2 [117]; Pax3 [118]
	Dorsal roof of closed neural tube bridge; Zic2 [104]; Msx1 [104]; Wnt1 [9, 119]; BMP6 [119]
	Tips of neural folds (surface ectoderm); Grainyhead-like 3 (in neural ectoderm at E8.5) [116]; Par1 and Par2 [120]