Table of Contents Author Guidelines Submit a Manuscript
Scientifica
Volume 2017, Article ID 7848926, 8 pages
https://doi.org/10.1155/2017/7848926
Research Article

Virulence and Antimicrobial Resistance in Campylobacter spp. from a Peruvian Pediatric Cohort

1Instituto de Medicina Tropical, Universidad Peruana Cayetano Heredia, Lima, Peru
2Department of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA
3ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain

Correspondence should be addressed to Joaquim Ruiz; moc.liamg@ojabart.ziuroj

Received 14 June 2017; Revised 10 August 2017; Accepted 29 August 2017; Published 9 October 2017

Academic Editor: Giuseppe Comi

Copyright © 2017 Angela Lluque et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. D. Kirk, S. M. Pires, R. E. Black et al., “World Health Organization estimates of the global and regional disease burden of 22 food-borne bacterial, protozoal, and viral diseases, 2010: a data synthesis,” PLoS Medicine, vol. 12, Article ID e1001921, 2015. View at Publisher · View at Google Scholar
  2. D. J. Bolton, “Campylobacter virulence and survival factors,” Food Microbiology, vol. 48, pp. 99–108, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Keithlin, J. Sargeant, M. K. Thomas, and A. Fazil, “Systematic review and meta-analysis of the proportion of Campylobacter cases that develop chronic sequelae,” BMC Public Health, vol. 14, no. 1, article no. 1203, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. A. C. T. Carvalho, G. M. Ruiz-Palacios, P. Ramos-Cervantes, L.-E. Cervantes, X. Jiang, and L. K. Pickering, “Molecular characterization of invasive and noninvasive Campylobacter jejuni and Campylobacter coli isolates,” Journal of Clinical Microbiology, vol. 39, no. 4, pp. 1353–1359, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. T. P. Eucker and M. E. Konkel, “The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling,” Cellular Microbiology, vol. 14, no. 2, pp. 226–238, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. E. Mendez-Arancibia, M. Vargas, S. Soto et al., “Prevalence of different virulence factors and biofilm production in enteroaggregative Escherichia coli isolates causing diarrhea in children in Ifakara (Tanzania),” American Journal of Tropical Medicine and Hygiene, vol. 78, no. 6, pp. 985–989, 2008. View at Google Scholar · View at Scopus
  7. C. Lübbert, “Antimicrobial therapy of acute diarrhoea: A clinical review,” Expert Review of Anti-Infective Therapy, vol. 14, no. 2, pp. 193–206, 2016. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Ruiz, P. Goñi, F. Marco et al., “Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates,” Microbiology and Immunology, vol. 42, no. 3, pp. 223–226, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. O. Serichantalergs, A. Dalsgaard, L. Bodhidatta et al., “Emerging fluoroquinolone and macrolide resistance of Campylobacter jejuni and Campylobacter coli isolates and their serotypes in Thai children from 1991 to 2000,” Epidemiology and Infection, vol. 135, no. 8, pp. 1299–1306, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Wang, Y. Dong, F. Deng et al., “Species shift and multidrug resistance of Campylobacter from chicken and swine, China, 2008–2014,” Journal of Antimicrobial Chemotherapy, vol. 71, no. 3, pp. 666–669, 2016. View at Publisher · View at Google Scholar
  11. H. Adler-Mosca, J. Lüthy-Hottenstein, G. Martinetti Lucchini, A. Burnens, and M. Altwegg, “Development of resistance to quinolones in five patients with campylobacteriosis treated with norfloxacin or ciprofloxacin,” European Journal of Clinical Microbiology ~~~~~~~~~^~^~^~^~~~~~~~~~~~amp; Infectious Diseases, vol. 10, no. 11, pp. 953–957, 1991. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Ruiz, “Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection,” Journal of Antimicrobial Chemotherapy, vol. 51, no. 5, pp. 1109–1117, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Ruiz, M. J. Pons, and C. Gomes, “Transferable mechanisms of quinolone resistance,” International Journal of Antimicrobial Agents, vol. 40, no. 3, pp. 196–203, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Zhao, G. H. Tyson, Y. Chen et al., “Whole-genome sequencing analysis accurately predicts antimicrobial resistance phenotypes in Campylobacter spp,” Applied and Environmental Microbiology, vol. 82, no. 2, pp. 459–466, 2016. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Yan, O. Sahin, J. Lin, and Q. Zhang, “Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure,” Journal of Antimicrobial Chemotherapy, vol. 58, no. 6, pp. 1154–1159, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Pérez-Boto, J. A. López-Portolés, C. Simón, S. Valdezate, and M. A. Echeita, “Study of the molecular mechanisms involved in high-level macrolide resistance of Spanish Campylobacter jejuni and Campylobacter coli strains,” Journal of Antimicrobial Chemotherapy, vol. 65, no. 10, Article ID dkq268, pp. 2083–2088, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Pollett, C. Rocha, R. Zerpa et al., “Campylobacter antimicrobial resistance in Peru: a ten-year observational study,” BMC Infectious Diseases, vol. 12, article no. 193, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. S.-K. Lim, D.-C. Moon, M. H. Chae et al., “Macrolide resistance mechanisms and virulence factors in erythromycin-resistant Campylobacter species isolated from chicken and swine feces and carcasses,” Journal of Veterinary Medical Science, vol. 78, no. 12, pp. 1791–1795, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Gomes, S. Martínez-Puchol, N. Palma et al., “Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin,” Critical Reviews in Microbiology, vol. 43, no. 1, pp. 1–30, 2017. View at Publisher · View at Google Scholar · View at Scopus
  20. S. R. Ladely, R. J. Meinersmann, M. D. Englen, P. J. Fedorka-Cray, and M. A. Harrison, “23S rRNA gene mutations contributing to macrolide resistance in Campylobacter jejuni and Campylobacter coli,” Foodborne pathogens and disease, vol. 6, no. 1, pp. 91–98, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Cagliero, C. Mouline, A. Cloeckaert, and S. Payot, “Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coli,” Antimicrobial Agents and Chemotherapy, vol. 50, no. 11, pp. 3893–3896, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Qin, Y. Wang, Q. Zhang et al., “Report of ribosomal RNA methylase gene erm(B) in multidrug-resistant Campylobacter coli,” Journal of Antimicrobial Chemotherapy, vol. 69, no. 4, Article ID dkt492, pp. 964–968, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Rozynek, K. Dzierzanowska-Fangrat, P. Jozwiak, J. Popowski, D. Korsak, and D. Dzierzanowska, “Prevalence of potential virulence markers in Polish Campylobacter jejuni and Campylobacter coli isolates obtained from hospitalized children and from chicken carcasses,” Journal of Medical Microbiology, vol. 54, no. 7, pp. 615–619, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Luangtongkum, Z. Shen, V. W. Seng et al., “Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host,” Antimicrobial Agents and Chemotherapy, vol. 56, no. 3, pp. 1300–1308, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. T. J. Ochoa, E. Chea-Woo, N. Baiocchi et al., “Randomized double-blind controlled trial of bovine lactoferrin for prevention of diarrhea in children,” Journal of Pediatrics, vol. 162, no. 2, pp. 349–356, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Andrzejewska, J. J. Klawe, B. Szczepańska, and D. Śpica, “Occurrence of virulence genes among Campylobacter jejuni and Campylobacter coli isolates from domestic animals and children,” Polish Journal of Veterinary Sciences, vol. 14, no. 2, pp. 207–211, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. M. E. Konkel, S. A. Gray, B. J. Kim, S. G. Garvis, and J. Yoon, “Identification of the enteropathogens Campylobacter jejuni and Campylobacter coli based on the cadF virulence gene and its product,” Journal of Clinical Microbiology, vol. 37, no. 3, pp. 510–517, 1999. View at Google Scholar · View at Scopus
  28. D. D. Bang, E. M. Nielsen, F. Scheutz, K. Pedersen, K. Handberg, and M. Madsen, “PCR detection of seven virulence and toxin genes of Campylobacter jejuni and Campylobacter coli isolates from Danish pigs and cattle and cytolethal distending toxin production of the isolates,” Journal of Applied Microbiology, vol. 94, no. 6, pp. 1003–1014, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Lee, W. Pan, P. Peñataro Yori et al., “Symptomatic and asymptomatic Campylobacter infections associated with reduced growth in peruvian children,” PLoS Neglected Tropical Diseases, vol. 7, no. 1, Article ID e2036, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Q. Al-Natour, A. R. Alaboudi, T. M. Osaili, and M. M. Obaidat, “Resistance of Campylobacter jejuni isolated from layer farms in northern jordan using microbroth dilution and disc diffusion techniques,” Journal of Food Science, vol. 81, no. 7, pp. M1749–M1753, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. D. J. Griggs, M. M. Johnson, J. A. Frost, T. Humphrey, F. Jørgensen, and L. J. V. Piddock, “Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment,” Antimicrobial Agents and Chemotherapy, vol. 49, no. 2, pp. 699–707, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. L. J. del Valle, L. Flores, M. Vargas et al., “Bartonella bacilliformis, endemic pathogen of the Andean region, is intrinsically resistant to quinolones,” International Journal of Infectious Diseases, vol. 14, no. 6, pp. e506–e510, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. J. Vila, M. Vargas, J. Ruiz, M. Corachan, M. T. Jiménez de Anta, and J. Gascon, “Quinolone resistance in enterotoxigenic Escherichia coli causing diarrhea in travelers to India in comparison with other geographical areas,” Antimicrobial Agents and Chemotherapy, vol. 44, no. 6, pp. 1731–1733, 2000. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Cagliero, C. Mouline, S. Payot, and A. Cloeckaert, “Involvement of the CmeABC efflux pump in the macrolide resistance of Campylobacter coli,” Journal of Antimicrobial Chemotherapy, vol. 56, no. 5, pp. 948–950, 2005. View at Publisher · View at Google Scholar · View at Scopus