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Abnormal Neural Network and Neurological Disorders

Call for Papers

Normal functions of human brain depend on properly connected and fully functional neural networks. Our knowledge about neurological diseases has been boosted by the progresses of modern network theory and detection technology over recent decades; meanwhile more and more evidences show the extremely close relationship between dysfunctions of brain-network organization and neurological diseases. Those abnormal activities of network could be conducted by disorders of structural connections among different regions, synaptic transmissions from neuron to neuron, functional interactions within neurons and glial cells, or even initiation and propagation of action potentials in a single neuron. Abnormalities of neural network not only are involved in the pathogenesis but also could be used as a new approach to monitor progression of neurological diseases and assess the effectiveness of clinical treatments.

The application of brain network science in clinical diagnosis and therapy, however, is still limited. Although an increasing number of genetic mutations have been identified to be responsible for neurological disorders, the molecular mechanisms of brain-network dysfunctions are largely unknown, which hinder the development of new medicine based on identifications of novel drug targets. Meanwhile, constructing of network-based diagnostic criteria for nervous system diseases requires the establishment of big clinical database and the advances of neural network theory. In this special issue, we wish to attract papers that deeply explore the role of brain-network organizations in different neurological disorders, which will promote studies of pathological mechanisms and developments of new therapeutic strategies. Submissions of original article and review are both encouraged in this special issue. Clinical studies related to current state of the art are also welcomed.

Potential topics include but are not limited to the following:

  • Modern network theory and its applications in the study of neurological disorders
  • Novel technologies to detect normal and/or abnormal activities of neural networks
  • Genetic mutations and epigenetic modifications involved in dysfunctions of neural networks and neurological disorders
  • The role of neural network in mental disorders: schizophrenia, depression, etc.
  • Epilepsy and neural networks: mechanisms, feature extraction, seizure prediction, and potential therapeutic strategies
  • Brain network science in neurodegenerative diseases: pathological correlations, behavioral phenotypes, and clinical diagnosis
  • The role of cerebrovascular abnormalities in dysfunctions of neural networks

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 6 April 2018
Publication DateAugust 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Hao QIAN, University of California, San Diego, USA

Guest Editors

  • Shidi ZHAO, Bengbu Medical College, Bengbu, China
  • Rongjing GE, Bengbu Medical College, Bengbu, China
  • Bing Zhou, University of California, San Diego, USA