A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on Sleep in Rats
Figure 2
Normalized EEG power spectra recorded by electrodes positioned above the prefrontal cortex and parietal cortex/dorsal (left) hippocampus (frequency bands as indicated in e and f), following systemic treatment with vehicle (control), WIN-2 (1 mg/kg), AM251 (2 mg/kg), or WIN-2 (1 mg/kg) + AM251 (2 mg/kg) for vigilance stages of wakefulness (a and b), NREM (c and d) and REM (e and f) sleep, respectively. Significant effects of treatment are depicted as WIN (WIN-2), AM (AM251), and WIN + AM (WIN-2 + AM251) for respective frequency bands in each subfigure (a–f). Rectangular markings indicate effects common to both prefrontal and parietal recording sites. The normalized power for all data points (0.77 Hz increments from 0 to 20 Hz) is represented as mean ± SEM.
