Sleep Disorders / 2012 / Article / Tab 1

Research Article

Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age: Results from the National Health and Nutrition Examination Survey 2005-2006

Table 1

Summary of evidence for and against the association of plasma homocysteine with sleep apnea.

No.Authors [Ref]YearType of study Results

1Chen et al. [17]2011Cross-sectional102Severity of OSA is associated with increased homocysteine levels in subjects with ischemic heart disease
2Basoglu et al. [14]2011Case control36 cases, 34 controlsNo association between plasma homocysteine and OSA in obese patients
3Cintra et al. [18]2011Matched case control75 cases, 75 controlsCysteine but not homocysteine is differentially distributed across OSA and non-OSA patients
4Wang et al. [27]2010Cross-sectional83 patients with OSA, 52 without OSAOxidative stress might induce high plasma homocysteine levels in elderly patients with OSA
5Cerbo et al. [16]2010Case report1Early onset homocystinuria is associated with apneic spells
6Sariman et al. [25]2010Cross-sectional38 cases of OSAPlasma homocysteine levels correlate with the severity of OSA
7Yavuz et al. [28]2008Cross-sectional62 patients of OSA, 12 controlsPlasma homocysteine levels are elevated in patients with OSA
8Ozkan et al. [23]2008Cross-sectional34 OSA patients, 15 controlsPlasma homocysteine levels are raised in patients with severe OSA
9Ryan et al. [24]2007Cross-sectional80 patients with OSA, 30 controlsPlasma homocysteine levels are not associated with either the risk or severity of OSA
10Kumor et al. [21]2006Cross-sectional47 patients of OSA, 12 controlsPlasma homocysteine levels are not differentially distributed across patients and controls of OSA
11Hachul de Campos et al. [19]2006Cross-sectional38 insomniac postmenopausal womenPlasma homocysteine levels are not associated with risk of apnea
12Can et al. [15]2006Cross-sectional30 OSA patients, 32 controlsSerum homocysteine levels are significantly higher in OSA patients
13Kokturk et al. [20]2006Cross-sectional72 OSA patients, 42 controlsSerum homocysteine is significantly increased in patients with OSA
14Svatikova et al. [26]2004Case control22 OSA patients, 20 controlsPlasma homocysteine levels exhibit diurnal variation and are not differentially distributed across patients and controls of OSA
15Lavie et al. [22]2001Case control237 cases of OSA, 108 controlsPatients with ischemic heart disease and OSA have elevated plasma homocysteine levels

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