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Sleep Disorders
Volume 2013, Article ID 128197, 8 pages
http://dx.doi.org/10.1155/2013/128197
Clinical Study

Melatonin Supplementation in Patients with Complete Tetraplegia and Poor Sleep

1Institute for Breathing and Sleep, Austin Hospital, Heidelberg, VIC 3084, Australia
2School of Social Sciences & Psychology, Victoria University, St. Albans, VIC 3021, Australia
3Victorian Spinal Cord Service, Austin Hospital, Heidelberg, VIC 3084, Australia
4Brain Sciences Institute, Swinburne University, Hawthorn, VIC 3122, Australia
5The Bronowski Institute of Behavioural Neuroscience, Kyneton, VIC 3444, Australia

Received 29 November 2012; Revised 15 January 2013; Accepted 30 January 2013

Academic Editor: Liborio Parrino

Copyright © 2013 Jo Spong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Biering-Sørensen and M. Biering-Sørensen, “Sleep disturbances in the spinal cord injured: an epidemiological questionnaire investigation, including a normal population,” Spinal Cord, vol. 39, no. 10, pp. 505–513, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. H. M. Verheggen, H. Jones, J. Nyakayiru et al., “Complete absence of evening melatonin increase in tetraplegics,” The FASEB Journal, vol. 26, no. 7, pp. 1–6, 2012. View at Google Scholar
  3. J. M. Zeitzer, N. T. Ayas, S. A. Shea, R. Brown, and C. A. Czeisler, “Absence of detectable melatonin and preservation of cortisol and thyrotropin rhythms in tetraplegia,” Journal of Clinical Endocrinology and Metabolism, vol. 85, no. 6, pp. 2189–2196, 2000. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Brzezinski, “Melatonin in humans,” The New England Journal of Medicine, vol. 336, no. 3, pp. 186–195, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. A. R. Gezici, A. Karakaş, R. Ergün, and B. Gündüz, “Rhythms of serum melatonin in rats with acute spinal cord injury at the cervical and thoracic regions,” Spinal Cord, vol. 48, no. 1, pp. 10–14, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. L. W. Kneisley, M. A. Moskowitz, and H. G. Lynch, “Cervical spinal cord lesions disrupt the rhythm in human melatonin excretion,” Journal of Neural Transmission, Supplement, no. 13, pp. 311–323, 1978. View at Google Scholar · View at Scopus
  7. Y. Li, D. H. Jiang, M. L. Wang, D. R. Jiao, and S. F. Pang, “Rhythms of serum melatonin in patients with spinal lesions at the cervical, thoracic or lumbar region,” Clinical Endocrinology, vol. 30, no. 1, pp. 47–56, 1989. View at Google Scholar · View at Scopus
  8. C. J. Mathias and H. L. Frankel, “Autonomic disturbances in spinal cord lesions,” in Autonomic Failure: A Textbook of clinical Disorders of the Autonomic Nervous System, C. J. Mathias and R. Bannister, Eds., pp. 494–513, Oxford Medical Publications, Oxford, UK, 1999. View at Google Scholar
  9. F. A. J. L. Scheer, J. M. Zeitzer, N. T. Ayas, R. Brown, C. A. Czeisler, and S. A. Shea, “Reduced sleep efficiency in cervical spinal cord injury; association with abolished night time melatonin secretion,” Spinal Cord, vol. 44, no. 2, pp. 78–81, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Dahlitz, B. Alvarez, J. Vignau, J. English, J. Arendt, and J. D. Parkes, “Delayed sleep phase syndrome response to melatonin,” The Lancet, vol. 337, no. 8750, pp. 1121–1124, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. I. Haimov, P. Lavie, M. Laudon, P. Herer, C. Vigder, and N. Zisapel, “Melatonin replacement therapy of elderly insomniacs,” Sleep, vol. 18, no. 7, pp. 598–603, 1995. View at Google Scholar · View at Scopus
  12. D. Kunz, R. Mahlberg, C. Müller, A. Tilmann, and F. Bes, “Melatonin in patients with reduced REM sleep duration: two randomized controlled trials,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 1, pp. 128–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. L. N. Pires, A. A. Benedito-Silva, L. Pinto, L. Souza, L. Vismari, and H. M. Calil, “Acute effects of low doses of melatonin on the sleep of young healthy subjects,” Journal of Pineal Research, vol. 31, no. 4, pp. 326–332, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. R. J. Wurtman and I. Zhdanova, “Improvement of sleep quality by melatonin,” The Lancet, vol. 346, no. 8988, p. 1491, 1995. View at Google Scholar · View at Scopus
  15. I. V. Zhdanova, R. J. Wurtman, C. Morabito, V. R. Piotrovska, and H. J. Lynch, “Effects of low oral doses of melatonin, given 2–4 hours before habitual bedtime, on sleep in normal young humans,” Sleep, vol. 19, no. 5, pp. 423–431, 1996. View at Google Scholar · View at Scopus
  16. R. L. Sack, A. J. Lewy, M. L. Blood, J. Stevenson, and L. D. Keith, “Melatonin administration to blind people: phase advances and entrainment,” Journal of Biological Rhythms, vol. 6, no. 3, pp. 249–261, 1991. View at Google Scholar · View at Scopus
  17. D. J. Skene and J. Arendt, “Circadian rhythm sleep disorders in the blind and their treatment with melatonin,” Sleep Medicine, vol. 8, no. 6, pp. 651–655, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Cohen, J. F. Ditunno, W. H. Donovan, and F. M. Maynard, “A test of the 1992 international standards for neurological and functional classification of spinal cord injury,” Spinal Cord, vol. 36, no. 8, pp. 554–560, 1998. View at Google Scholar · View at Scopus
  19. H. J. Burgess and L. F. Fogg, “Individual differences in the amount and timing of salivary melatonin secretion,” PLoS ONE, vol. 3, no. 8, Article ID e3055, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. American Association of Sleep Medicine, “Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force,” Sleep, vol. 22, no. 5, pp. 667–689, 1999. View at Google Scholar
  21. A. Rechtschaffen and A. Kales, A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages in Human Subjects, Brain Information Service, Brain Information Institute, University of California, Los Angeles, Calif, USA, 1968.
  22. M. Gillberg, G. Kecklund, and T. Akerstedt, “Relations between performance and subjective ratings of sleepiness during a night awake,” Sleep, vol. 17, no. 3, pp. 236–241, 1994. View at Google Scholar · View at Scopus
  23. M. Partinen and T. Gislason, “Basic nordic sleep questionnaire (BNSQ): a quantitated measure of subjective sleep complaints,” Journal of Sleep Research, Supplement, vol. 4, supplement 1, pp. 150–155, 1995. View at Google Scholar · View at Scopus
  24. J. Spong, D. Riley, J. Ross, R. J. Pierce, D. J. Brown, and D. J. Berlowitz, “Sleep health in tetraplegia—a Victorian population survey,” Respirology, vol. 13, article A73, 2008. View at Google Scholar
  25. D. J. Berlowitz, J. Spong, I. Gordon, M. E. Howard, and D. J. Brown, “Relationships between objective sleep indices and symptoms in a community sample of people with tetraplegia,” Archives of Physical Medicine and Rehabilitation, vol. 93, no. 7, pp. 1246–1252, 2012. View at Google Scholar
  26. F. Biering-Sorensen, M. Biering-Sorensen, and J. Hilden, “Reproducibility of Nordic sleep questionnaire in spinal cord injured,” Paraplegia, vol. 32, no. 11, pp. 780–786, 1994. View at Google Scholar · View at Scopus
  27. M. Kabuto, I. Namura, and Y. Saitoh, “Nocturnal enhancement of plasma melatonin could be suppressed by benzodiazepines in humans,” Endocrinologia Japonica, vol. 33, no. 3, pp. 405–414, 1986. View at Google Scholar · View at Scopus
  28. S. P. James, W. B. Mendelson, D. A. Sack, N. E. Rosenthal, and T. A. Wehr, “The effect of melatonin on normal sleep,” Neuropsychopharmacology, vol. 1, no. 1, pp. 41–44, 1987. View at Google Scholar · View at Scopus
  29. S. P. James, D. A. Sack, N. E. Rosenthal, and W. B. Mendelson, “Melatonin administration in insomnia,” Neuropsychopharmacology, vol. 3, no. 1, pp. 19–23, 1990. View at Google Scholar · View at Scopus
  30. S. Nishino, E. Mignot, and W. Dement, “Sedative-hypnotics,” in Essentials of Clinical Psychopharmacology, A. Schatzberg and C. Nemeroff, Eds., pp. 283–301, American Psychiatric, Washington, DC, USA, 2001. View at Google Scholar
  31. D. Dawson and S. M. Armstrong, “Chronobiotics—drugs that shift rhythms,” Pharmacology and Therapeutics, vol. 69, no. 1, pp. 15–36, 1996. View at Publisher · View at Google Scholar · View at Scopus
  32. R. L. Sack, R. J. Hughes, D. M. Edgar, and A. J. Lewy, “Sleep-promoting effects of melatonin: at what dose, in whom, under what conditions, and by what mechanisms?” Sleep, vol. 20, no. 10, pp. 908–915, 1997. View at Google Scholar · View at Scopus
  33. F. A. J. L. Scheer and C. A. Czeisler, “Melatonin, sleep, and circadian rhythms,” Sleep Medicine Reviews, vol. 9, no. 1, pp. 5–9, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Cagnacci, J. A. Elliott, and S. S. C. Yen, “Melatonin: a major regulator of the circadian rhythm of core temperature in humans,” Journal of Clinical Endocrinology and Metabolism, vol. 75, no. 2, pp. 447–452, 1992. View at Publisher · View at Google Scholar · View at Scopus
  35. K. Kräuchi, C. Cajochen, M. Pache, J. Flammer, and A. Wirz-Justice, “Thermoregulatory effects of melatonin in relation to sleepiness,” Chronobiology International, vol. 23, no. 1-2, pp. 475–484, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. C. J. van den Heuvel, S. A. Ferguson, M. Mila MacChi, and D. Dawson, “Melatonin as a hypnotic: con,” Sleep Medicine Reviews, vol. 9, no. 1, pp. 71–80, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. I. V. Zhdanova, “Melatonin as a hypnotic: pro,” Sleep Medicine Reviews, vol. 9, no. 1, pp. 51–65, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Dawson, N. L. Rogers, C. J. van den Heuvel, D. J. Kennaway, and K. Lushington, “Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs,” Journal of Biological Rhythms, vol. 13, no. 6, pp. 532–538, 1998. View at Google Scholar · View at Scopus
  39. R. J. Hughes, R. L. Sack, and A. J. Lewy, “The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement,” Sleep, vol. 21, no. 1, pp. 52–68, 1998. View at Google Scholar · View at Scopus
  40. I. V. Zhdanova, R. J. Wurtman, H. J. Lynch et al., “Sleep-inducing effects of low doses of melatonin ingested in the evening,” Clinical Pharmacology and Therapeutics, vol. 57, no. 5, pp. 552–558, 1995. View at Publisher · View at Google Scholar · View at Scopus