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Sleep Disorders
Volume 2014, Article ID 767181, 9 pages
http://dx.doi.org/10.1155/2014/767181
Review Article

Daytime Sleepiness and Parkinson’s Disease: The Contribution of the Multiple Sleep Latency Test

1Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Universidade Federal de Pernambuco, Recife, PE, Brazil
2Hospital das Clinicas, Universidade Federal de Pernambuco, Recife, PE, Brazil

Received 20 January 2014; Revised 2 June 2014; Accepted 20 June 2014; Published 10 July 2014

Academic Editor: Michael J. Thorpy

Copyright © 2014 Marcelo Ataide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Sleep disorders are major nonmotor manifestations of patients with Parkinson’s disease (PD), and excessive daytime sleepiness (EDS) is one of the most common symptoms. Objective. We reviewed a current literature concerning major factors that influence EDS in PD patients, using Multiple Sleep Latency Test (MSLT). Methods. A Medline search found 23 studies. Results. The presence of EDS was observed in 12.7% to 47% in patients without complaints of daytime sleepiness and 47% to 66.7% with complaints of daytime sleepiness. Despite being recognized by several authors, major factors that influence EDS, such as severity of motor symptoms, use of dopaminergic medications, and associated sleep disturbances, presented contradictory data. Conclusions. Available data suggest that the variability of the results may be related to the fact that it was conducted with a small sample size, not counting the neuropathological heterogeneity of the disease. Thus, before carrying out longitudinal studies with significant samples, careful analysis should be done by assigning a specific agent on the responsibility of EDS in PD patients.