Sleep Disorders / 2015 / Article / Tab 6

Review Article

Computer-Assisted Diagnosis of the Sleep Apnea-Hypopnea Syndrome: A Review

Table 6

Validation of respiratory event classification approaches (see text for details). = number of participants/recordings; AHI = Apnea-Hypopnea Index; TR = training set; TS = testing set; A = apnea; H = hypopnea; N = normal breathing; CA = central apnea; OA = obstructive apnea; MA = mixed apnea; PPV = positive predictive value; NPV = negative predictive value; AUC = areas under ROC curve; ACC = accuracy; ICC = intraclass correlation coefficient; = weighted Kappa coefficient; = Pearson’s linear correlation coefficient; S = single validation set; CV = cross-validation. 1Minimum and maximum values.

Study sourceDatabase/ratio maleAge (mean ± std.)AHI (mean ± std.)Reference testEvent definitionNumber of eventsSensitivity (%)Specificity (%)OthersValidation

Reisch et al. [46]Ambrock Hospital, Germany51/0.9051.29.1Same-night Level 1 PSGSee [46]50 (H1) 50 (H2) 50 (OA) 50 (MA) 50 (CA)56–85 (H1) 
74–85 (H2) 
25–94 (OA) 
82–88 (MA) 
60–88 (CA)
90–98 (H1) 
90–98 (H2) 
96–100 (OA) 
87–100 (MA) 
96–100 (CA)
TR/TS

Al-Ashmouny et al. [54]Cairo University, Egypt—/—3626S

Taha et al. [55]Wisconsin sleep cohort study [71]10/—51.8 ± 7.1718.2 ± 16.2Same-night Level 1 PSGSee [55]142 (OA) 41 (CA) 
7 (MA)
68.3 (OA)  
75.6 (CA) 
100 (MA)
96.0 (OA) 
100 (CA) 
77.5 (MA)
ACC = 0.71S

Sommermeyer
et al. [57]
Sahlgrenska University Hospital, Sweden, and sleep centers in Ulm, Berlin and Nuremberg, Germany66/0.6354 ± 1419.3 ± 18.5Same-night Level 3 PGSee [57]3673 (OA) 
1042 (CA)
= 0.87 (OA) 
= 0.95 (CA)
S

Steltner et al. [58]Freiburg University Hospital, Germany19/1.0059.9 ± 10.616.5 ± 13.29Same-night Level 1 PSGSee [58]3957 (scorer 1) 
2966 (scorer 2)
Scorer 1 =  
60 (H) 
63 (OA) 
20 (MA) 
37 (CA) 
Scorer 2 =  
72 (H) 
52 (OA) 
0 (MA) 
39 (CA)
= 0.45 ± 0.15 
(scorer 1) 
0.40 ± 0.19 (scorer 2)
CV (Leave-one-out P)

Várady et al. [59]6/—PSG (unknown level or timing)189 (5 min each)ACC = 0.91S

Houdt et al. [60]Sleep Medicine Center, Kempenhaeghe, The Netherlands11/0.9149.1 ± 11.416.5 ± 13.3Same-night Level 1 PSGAASM2007ACC = 0.68S

Al-Ani et al. [79]Raymond Poincare Hospital, France—/—ACC = 0.90–1.00

Fontenla-Romero et al. [80]Complejo Hospitalario Universitario de A Coruña, Spain6/—Same-night Level 1 PSG40 (OA) 
40 (MA) 
40 (CA)
ACC =  
0.81 (OA) 
0.80 (MA) 
0.90 (CA)
CV (100 × 10 K-fold)

Tagluk et al. [81]Medicine Faculty of Dicle University, Turkey21/0.7121–671Same-night Level 1 PSG120 (OA) 
120 (CA) 
120 (MA)
ACC =  
0.73 (OA) 
0.94 (CA) 
0.66 (MA)
TR/TS (240)

Tagluk and Sezgin [82] Medicine Faculty of Dicle University, Turkey21/0.7121–671Same-night Level 1 PSG120 (OA) 
120 (CA) 
120 (MA)
ACC =  
0.85 (OA) 
0.94 (CA) 
0.78 (MA)
TR/TS (240)

Sezgin and
Emin Tagluk [78]
Medicine Faculty of Dicle University, Turkey21/0.6721–571Same-night Level 1 PSG120 (OA) 
120 (CA) 
120 (MA)
ACC = 0.86 (OA) 
0.95 (CA) 
0.80 (MA)
TR/TS (240)

Guijarro-Berdiñas et al. [83]Complejo Hospitalario Universitario de A Coruña, Spain6/—Same-night Level 1 PSG40 (OA) 
40 (MA) 
40 (CA)
89.6 (OA) 
92.2 (MA) 
89.0 (CA)
97.1 (OA) 
89.6 (MA) 
98.6 (CA)
ACC =  
0.95 (OA) 
0.90 (MA) 
0.95 (CA)
CV (100 × 10 K-fold)

Maali et al.
[77]
Concord Hospital, Australia—/—ACC = 0.84

Morgenstern
et al. [84]
Sleep Lab, Bethanien Hospital, Germany28/—52.6 ± 15.618.9 ± 18.5Same-night Level 1 PSGAASM1999769 (H)9090ACC = 0.90CV (100 K-fold)

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