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Sleep Disorders
Volume 2015 (2015), Article ID 279263, 6 pages
http://dx.doi.org/10.1155/2015/279263
Research Article

Periodic Breathing and Behavioral Awakenings at High Altitude

1Division of Emergency Medicine, Duke University, Durham, NC, USA
2Division of Wilderness Medicine, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA
3Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA

Received 2 June 2015; Revised 13 September 2015; Accepted 14 September 2015

Academic Editor: Marco Zucconi

Copyright © 2015 Daniel J. Shogilev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To study the relationship between nocturnal periodic breathing episodes and behavioral awakenings at high altitude. Methods. Observational study. It is 6-day ascent of 4 healthy subjects from Besisahar (760 meters) to Manang (3540 meters) in Nepal in March 2012. A recording pulse oximeter was worn by each subject to measure their oxygen saturation and the presence of periodic breathing continuously through the night. An actigraph was simultaneously worn in order to determine nocturnal behavioral awakenings. There were no interventions. Results. 187-hour sleep at high altitude was analyzed, and of this, 145 hours (78%) had at least one PB event. At high altitude, 10.5% (95% CI 6.5–14.6%) of total sleep time was spent in PB while 15 out of 50 awakenings (30%, 95% CI: 18–45%) occurring at high altitudes were associated with PB (). Conclusions. Our data reveals a higher than expected number of behavioral awakenings associated with PB compared to what would be expected by chance. This suggests that PB likely plays a role in behavioral awakenings at high altitude.