CPAP Treatment Partly Normalizes Sleep Spindle Features in Obstructive Sleep Apnea
Table 1
Median and range of the sleep parameters in the study groups and the values of the comparisons.
Controls
Pre-CPAP
CPAP
Controls versus pre-CPAP
Controls versus CPAP
Pre-CPAP versus CPAP
Median
Range
Median
Range
Median
Range
value
value
value
Age
48.5
34–60
50.0
37–65
0.170
BMI
24.9
20.1–30.2
29.6
24.7–41.4
<0.001
TST min
431.5
348–527
435.8
375–532
395
264–503
0.344
0.256
0.006
SEI%
90.6
76.7–97.1
93.2
80.0–97.5
92.0
58.2–97.0
0.417
0.946
0.322
N1%
5.4
2.2–16.3
5.0
1.2–11.2
4.8
1.5–16.1
0.285
0.617
0.490
N2%
60.0
45.4–71.6
73.0
59.5–85.3
68.0
46.8–79.0
<0.001
0.016
0.005
N3%
12.5
2.1–25.4
2.6
0.0–14.1
6.6
0.6–29.3
<0.001
0.029
0.002
REM%
20.0
13.1–27.8
16.8
8.6–27.3
17.6
11.4–26.4
0.117
0.285
0.563
SL min
8.3
3.5–32.5
6.3
1.0–33.0
4.5
2.0–22.0
0.163
0.014
0.162
AHI /h
1.8
0.0–4.9
42.0
14.0–103.0
0.7
0.0–14.0
<0.001
0.080
<0.001
ARI /h
12.8
4.3–22.8
30.0
8.0–99.6
16.0
4.6–27.0
<0.001
0.152
<0.001
ODI4 /h
0.5
0.0–6.0
34.0
0.0–88.0
0.8
0.0–3.0
<0.001
0.496
<0.001
Sa02min%
91.0
83.0–95.0
79.0
62.0–92.0
90.5
84.0–94.0
<0.001
0.713
<0.001
Sa02mean%
95.9
93.0–97.0
93.6
83.1–97.5
96.1
93.3–97.3
<0.001
0.551
<0.001
Mann-Whitney test; Wilcoxon test. The Bonferroni corrected values are reported: Bonferroni correction factor = 3. BMI = body mass index; min = minutes; n/h = number/hour; TST = total sleep time; SEI% = sleep efficiency index; N1%–N3% = time percentage of sleep stages N1–N3 referred to as TST; REM% = time percentage of REM sleep referred to as TST; SL = sleep latency; AHI = apnea/hypopnea index; ARI = arousal index; ODI4 = oxygen desaturation index; Sa02min% = minimum oxygen saturation percentage; Sa02mean% = mean oxygen saturation percentage. Bold font = statistically significant value.
