Sleep Disorders

Research Article

The Importance of Apneic Events in Obstructive Sleep Apnea Associated with Acute Coronary Syndrome

Table 1

Baseline characteristics of patients according to severity of OSA. Data are expressed as mean±SD on number (%). ESS, Epworth Sleepiness Scale; PSQI, Pittsburgh Sleep Quality Index; AHI, apnea-hypopnea index; STEMI, ST elevation myocardial infarction; UA, unstable angina; PCI, percutaneous coronary intervention; LVEF, left ventricle ejection fraction.


	Overall (n = 53)	AHI < 15/h and arousal index < 10/h n = 14	AHI ≥ 15/h and arousal index ≥ 10/h n = 39	p-value

Age (yrs)	59,5 ± 9,6	56 ± 9	60,8 ± 9,7	0,102

Male	43 (81%)	11 (78,5%)	32 (82%)	0,528

BMI (kg/m²)	28,5 ± 4,1	27 ± 3,9	28,9 ± 4,1	0,203

Neck circumference (cm)	41,5 ± 3,5	40,7 ± 3,7	41,8 ± 3,4	0,343

Waist circumference (cm)	106,4 ± 12,3	99,7 ± 11,1	106,4 ± 11,8	0,023

Laboratory values

Creatinine (µmol/L)	79,5 ± 18,8	72,8 ± 12	82 ± 20,3	0,114

NT-proBNP (ng/mL)	1553,7 ± 2830	1263,8 ± 1766,3	1667,9 ± 3169,3	0,845

Peak Troponin I (ng/mL)	44,7 ± 51,6	35,3 ± 35,2	48 ± 56,4	0,755

LDL (g/L)	1,3 ± 0,44	1,3 ± 0,46	1,27 ± 0,44	0,755

HbA1c (%)	6,36 ± 1,3	6,28 ± 1,17	6,39 ± 1,35	0,754

Sleep related parameters

ESS score (baseline)	6,6 ± 3,9	5,7 ± 2,8	6,9 ± 4,2	0,264

High risk Berlin score (baseline)	22 (41,5%)	4 (30,7%)	18 (46,1%)	0,171

PSQI score (baseline)	6,4 ± 3,2	6,25 ± 2,9	6,5 ± 3,3	0,969

ESS score (2 mo. after)	6,1 ± 3,2	4,3 ± 1,4	6,6 ± 3,4	0,054

High risk Berlin score (2 mo. after)	19 (35,8%)	1 (7,2%)	18 (46,1%)	0,05

PSQI score (2 mo. after)	6,4 ± 3,2	4,3 ± 2,3	6,8 ± 3,2	0,082

AHI (/h)	35,1 ± 16,8	15,1 ± 3,9	42,3 ± 13,4	< 0,001

Arousal index (/h)	22,5 ± 16,5	6,4 ± 4,3	28,2 ± 15,3	< 0,001

Mean SpO2 (%)	92,6 ± 1,6	93,4 ± 2,2	92,3 ± 1,2	0,012

Time SpO2 < 90% (% sleep time)	10,4 ± 16,5	8,2 ± 22,6	11,2 ± 14	0,009

ACS characteristics

SYNTAX score	12,2 ± 9,2	9,8 ± 4,2	13,1 ± 10,4	0,634

Type of ACS				0,776

STEMI	35 (66%)	10 (71,4%)	25 (64,1%)

NSTEMI	15 (28,3%)	3 (21,4%)	12 (30,7%)

UA	3 (5,7%)	1 (7,2%)	2 (5,2%)

Number of diseased vessels				0,94

1	25 (47%)	7 (50%)	18 (46%)

2	19 (36%)	5 (36%)	14 (36%)

3	9 (17%)	2 (14%)	7 (18%)

Pre-PCI TIMI flow grade 0-1	23 (43,4%)	4 (28,6%)	19 (48,7%)	0,161

Echocardiography

LVEF (%)	56 ± 9,7	57,5 ± 7,7	55,5 ± 10,4	0,762