The Importance of Apneic Events in Obstructive Sleep Apnea Associated with Acute Coronary Syndrome

Table 2

Comparison between the more apneic patients vs. less apneic patients. Data are expressed as mean±SD or number (%). ACS, acute coronary syndrome; STEMI, ST elevation myocardial infarction; UA, unstable angina; PCI, percutaneous coronary intervention; LVEF, left ventricle ejection fraction; ESS, Epworth Sleepiness Scale; AHI, apnea-hypopnea index; CPAP, continuous positive airway pressure.

	Overall; (n = 53)	Apneic coef. < 37%; n = 26	Apneic coef. ≥ 37%; n = 27	p-value
Age (yrs)	59,5 ± 9,6	57,2 ± 9,1	61,8 ± 9,8	0,087
Male	43 (81%)	23 (88,4%)	20 (74%)	0,162
BMI (kg/m^2)	28,5 ± 4,1	28,1 ± 3,9	28,8 ± 4,4	0,561
Neck circumference (cm)	41,5 ± 3,5	41,2 ± 3,4	41,7 ± 3,6	0,652
Waist circumference (cm)	106,4 ± 12,3	105,7 ± 9,7	107,2 ± 15	0,729
Laboratory values
NT-proBNP (ng/mL)	1553,7 ± 2830	480 ± 621,3	1879,9 ± 2141,9	0,001
Peak Troponin I (ng/mL)	44,7 ± 51,6	29,7 ± 36,1	63,4 ± 63,2	0,016
ACS characteristics
SYNTAX score	12,2 ± 9,2	10,2 ± 5,9	15,8 ± 11,5	0,049
Type of ACS				0,031
STEMI	35 (66%)	14 (53,8%)	21 (77,7%)
NSTEMI	15 (28,3%)	9 (34,6%)	6 (22,3%)
UA	3 (5,7%)	3 (11,6%)	0 (0%)
Number of diseased vessels				0,43
1	25 (47%)	13 (50%)	12 (44,4%)
2	19 (36%)	10 (38,4%)	9 (33,3%)
3	9 (17%)	3 (11,6%)	6 (22.3%)
Pre-PCI TIMI flow grade 0-1	23 (43,4%)	10 (38,4%)	13 (48,1%)	0,332
LVEF (%)	56 ± 9,7	59,5 ± 6,5	53,3 ± 11,4	0,023
Sleep related parameters
ESS score (2 mo. after)	6,1 ± 3,2	5,5 ± 2,8	6,7 ± 3,5	0,210
High risk Berlin score (2 mo. after)	19 (35,8%)	6 (33,3%)	13 (52%)	0,183
AHI (/h)	35,1 ± 16,8	31,3 ± 16,3	40 ± 14,5	0,03
Arousal index (/h)	22,5 ± 16,5	16,5 ± 11,8	22,3 ± 12,6	0,083
Desaturation index (/h)	22,2 ± 15,8	16,4 ± 13,8	28,8 ± 15,6	0,004
Mean SpO2 (%)	92,6 ± 1,6	92,4 ± 1,9	92,7 ± 1,3	0,597
Time SpO2 < 90% (% sleep time)	10,4 ± 16,5	8,7 ± 11,3	12,2 ± 20,7	0,438
Compliance to CPAP treatment; (≥ 4 hours of CPAP therapy)	27 (50,9%)	8 (32%)	19 (73%)	0,016