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Scientific Programming
Volume 12, Issue 1, Pages 25-43
http://dx.doi.org/10.1155/2004/323981

Individual-Based Simulation of the Clustering Behaviour of Epidermal Growth Factor Receptors

Jacki P. Goldman,1,2 William J. Gullick,2 and Colin G. Johnson1

1Computing Laboratory, University of Kent, Canterbury, Kent, CT2 7NF, UK
2Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK

Received 17 February 2004; Accepted 17 February 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This paper describes ongoing work on a project to simulate the behaviour of epidermal growth factor receptors. These are structures which can be found on the surface of cells in the body, which receive and process chemical signals concerned with cell growth. The implementation of a program which simulates the stimulation and clustering behaviour of these structures is described, then the paper discusses how the simulation can be scaled up so that a whole cell can be simulated on a tractable timescale. Finally some early results are given which show the effect of changing parameters in the system, and discuss ongoing work on calibrating the simulation against results from experiments.