A Crossover Comparison of the Sensitivity and the Specificity between BIS and AEP in Predicting Unconsciousness in General Anesthesia

Table 4

Descriptive statistics of drug concentrations, BIS, and AEP at different stages of induction.

Mean ± SD, median (range)	Predicted blood concentration μg·ml^−1		Effect-site concentration μg·ml^−1		BIS		AEP
Stage	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane
Baseline	—	—	—	—	96.5 ± 3.19 97.5 [84–98]	96.6 ± 2.01 97 [90–98]	83.0 ± 10.6 82 [58–99]	79.4 ± 12.64 78.5 [48–99]
Sedation	2.0 ± 0.44 2 [1.5–3.0]	2.7 ± 0.72 2.6 [1.2–3.8]	1.2 ± 0.29 1.2 [0.7–1.7]	1.6 ± 0.53 1.55 [0.6–2.45]	81.2 ± 6.36 82 [64–93]	83.8 ± 14.63 86.5 [41–98]	58.1 ± 23.10 60 [20–95]	63.1 ± 19.45 65.5 [25–99]
Unconsciousness	3.5 ± 0.83 3.5 [2.0–5.5]	3.4 ± 0.62 3.4 [2.4–4.6]	2.4 ± 0.62 2.4 [1.2–3.7]	2.3 ± 0.68 2.25 [1.3–3.95]	58.0 ± 10.33 56.5 [40–74]	59.2 ± 19.18 60 [19–86]	34.1 ± 14.45 30 [10–55]	51.7 ± 20.02 46 [22–89]
Anesthesia	4.2 ± 0.98 4 [2.5–6.0]	4.1 ± 0.87 3.95 [2.6–5.95]	3.2 ± 0.81 3.25 [1.7–4.9]	3.0 ± 0.79 3.1 [1.7–4.25]	47.8 ± 8.67 46.5 [36–66]	41.05 ± 16.05 40 [14–72]	17.78 ± 5.97 17.5 [8–29]	38.7 ± 22.97 30.5 [12–83]