Comparing Supervised Exercise Therapy to Invasive Measures in the Management of Symptomatic Peripheral Arterial Disease

Table 4

Supervised exercise plus invasive measures (open surgery or EVR) versus monotherapy.

Study	Follow-up	ABPI			MWD			ICD
		Baseline	Endpoint		Baseline	Endpoint		Baseline	Endpoint
Lundgren et al. [30]
Surgery	13 months	0.55	—		209	570		85	405
SET		0.59	—		180	654		70	559
Surgery + SET		0.59	—	<0.001	183	459	0.05	67	187	0.006
Badger et al. [31]
Surgery	6 months	—	—		—	—		—	—	—
Surgery + SET		—	—	0.02	—	—	0.001	—	—	—
Greenhalgh et al. [26]; (Aortoiliac)
SET	24 months	0.66	0.74		126	168		—	—	—
EVR + SET		0.68	0.90	0.02	114	354	0.05	—	—	—
Greenhalgh et al. [26]; (Femoropopliteal)
SET	24 months	0.69	0.72		126	155		—	—	—
EVR + SET		0.66	0.83	0.01	133	245	0.4	—	—	—
Kruidenier et al. [27]
EVR	6 months	0.71	0.93		282	685		343	547
EVR + SET		0.69	0.88	0.755	186	956	0.001	293	842	0.001
Mazari et al. [25]
EVR	12 months	0.71	0.9		77	146		31	75
SET		0.72	0.84		83	215		42	97
EVR + SET		0.64	0.92	0.93	85	187	0.259	43	99	0.484
Bø et al. [28]
EVR	3 months	—	—		213	427		94	267
EVR + SET		—	—	<0.001	385	584	NS	101	456	NS

ABPI: ankle brachial pressure index; MWD: maximal walk distance; ICD: intermittent claudication distance; EVR: endovascular revascularization; SET: supervised exercise therapy. Distances in metres unless otherwise stated. represents significant improvement favouring combined treatment. value represents statistical comparison of interventions. — represents nonreported figures.