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Surgery Research and Practice
Volume 2016, Article ID 4328089, 6 pages
http://dx.doi.org/10.1155/2016/4328089
Research Article

Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study

12nd Department of Surgery, “Aretaieio” Hospital, National and Kapodistrian University of Athens, School of Medicine, 11528 Athens, Greece
2Department of Pathology, “Aretaieio” Hospital, National and Kapodistrian University of Athens, School of Medicine, 11528 Athens, Greece
3Animal House Facility/Experimental Unit, “Aretaieio” Hospital, National and Kapodistrian University of Athens, School of Medicine, 11528 Athens, Greece
41st Department of Anesthesiology, “Aretaieio” Hospital, National and Kapodistrian University of Athens, School of Medicine, 11528 Athens, Greece

Received 25 December 2015; Accepted 14 March 2016

Academic Editor: Christina Fotopoulou

Copyright © 2016 Stamatoula Drakopoulou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction and Aim. With the implementation of multimodal analgesia regimens, Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are often administered for optimal pain control and reduction of opioid use. The aim of the study was to examine the effects of lornoxicam, a NSAID, on anastomotic healing employing an animal model. Materials and Methods. A total of 28 Wistar rats were randomly assigned in two groups. All animals underwent ascending colonic transection followed by an end-to-end hand sewn anastomosis. Group 1 received intraperitoneally lornoxicam before and daily after surgery. Group 2 received intraperitoneally an equal volume of placebo. Half of the animals in each group were euthanized on the 3rd pod and the remaining on the 7th pod. Macro- and microscopic indicators of anastomotic healing were compared using a two-tailed Fisher exact test. Results. The lornoxicam group significantly decreased fibroblast in growth and reepithelization of the mucosa at the anastomotic site on the 3rd pod and significantly increased occurrence of deep reaching defects, necrosis, and microabscess on the 7th pod. Conclusion. Lornoxicam administration during the perioperative period adversely affects histologic parameters of intestinal anastomotic healing. These effects of lornoxicam administration were not found to induce significant increase of anastomotic dehiscence in the rat model.