TY - JOUR A2 - Sperti, Cosimo AU - Fernandez-Placencia, Ramiro AU - Berrospi-Espinoza, Francisco AU - Uribe-Rivera, Karla AU - Medina-Cana, Jose AU - Chavez-Passiuri, Ivan AU - Sanchez-Bartra, Nestor AU - Paredes-Galvez, Kori AU - Luque-Vasquez Vasquez, Carlos AU - Celis-Zapata, Juan AU - Ruiz-Figueroa, Eloy PY - 2021 DA - 2021/02/28 TI - Preoperative Predictors for 90-Day Mortality after Pancreaticoduodenectomy in Patients with Adenocarcinoma of the Ampulla of Vater: A Single-Centre Retrospective Cohort Study SP - 6682935 VL - 2021 AB - Background. The standard treatment for ampullary adenocarcinoma is pancreaticoduodenectomy. Identification of preoperative risk factors might help the clinician to select patients fit for resection and potentially decrease morbidity and mortality after PD. We conducted a cohort study to determine the preoperative factors related to 90-day severe morbidity and mortality after PD. Methods. We conducted a retrospective cohort study in patients with a diagnosis of ampullary adenocarcinoma who underwent an open PD between January 2010 and December 2019 at our tertiary centre. Results. Independent preoperative predictors of mortality were the albumin-bilirubin (ALBI) grade 3 (OR: 21.7; CI 95: 2.1–226.9; p=0.01) and the estimated glomerular filtration rate (eGFR) <90 mL/min/1.73 m2 (OR: 17.7; CI 95: 1.8–172.6; p=0.013). The eGFR <90 mL/min/1.73 m2 (OR = 6.6; CI 95: 1.9–23.4; p=0.003) and prothrombin time (OR = 1.5; CI 95; 1.1–2.1; p=0.005) were independent predictors for severe morbidity. Conclusion. These findings suggest that baseline renal function measured by the eGFR and liver function categorized with the ALBI grading are predictors of severe morbidity and mortality. Thus, they should be considered when selecting patients for PD or the use of neoadjuvant treatments. Further research is warranted. SN - 2356-7759 UR - https://doi.org/10.1155/2021/6682935 DO - 10.1155/2021/6682935 JF - Surgery Research and Practice PB - Hindawi KW - ER -