Preoperative Predictors for 90-Day Mortality after Pancreaticoduodenectomy in Patients with Adenocarcinoma of the Ampulla of Vater: A Single-Centre Retrospective Cohort Study
Table 4
Univariate and multivariable analysis for prediction of 90-day severe morbidity (Clavien–Dindo ≥IIIb) after pancreaticoduodenectomy for ampullary adenocarcinoma.
Severe morbidity
Univariate
Multivariable
No (n = 80)
Yes (n = 21)
value
value
OR
CI 95
Age, mean ± SD
59 (10.8)
62.5 (12.9)
0.141φ
Male sex, count (%)
35 (43.8)
12 (57.1)
0.273χ
Body mass index (kg/m2), mean ± SD
24.6 (4.2)
26.1 (4.7)
0.322φ
MELD score, mean ± SD
10.4 (3.9)
11.8 (4.8)
0.584φ
ALBI grade, count (%)
0.653χ
ALBI 1
25 (31.3)
5 (23.8)
ALBI 2
36 (45)
10 (47.6)
ALBI 3
16 (20)
6 (28.6)
Undetermined
3 (3.7)
0
ASA score, count (%)
0.479χ
ASA I
2 (2.5)
0
ASA II
60 (75)
14 (66.7)
ASA III
18 (22.5)
7 (33.3)
eGFR <90 mL/min/1.73 m2, count (%)
10 (12.5)
8 (38.1)
0.011χ
0.003
6.6
1.9
23.4
Preoperative RBC transfusion, count (%)
22 (27.5)
7 (33.3)
0.599χ
Preoperative biliary drainage, count (%)
23 (28.7)
6 (28.6)
0.987χ
Haemoglobin in g/L, mean ± SD†
116.6 (14)
116.5 (17.5)
0.487φ
Platelet count in 109/L, mean ± SD†
339.1 (162)
300 (90)
0.682φ
International Normalized Ratio, mean ± SD†
1.08 (0.1)
1.17 (0.2)
0.072φ
0.800
Prothrombin time, mean ± SD†
12.9 (1.7)
14.2 (2.2)
0.012φ
0.005
1.5
1.1
2.1
Serum total bilirubin in µmol/L, mean ± SD†
61.7 (78.2)
80.1 (100.7)
0.741φ
Serum creatinine in µmol/L, mean ± SD†
56.3 (14.6)
66.6 (17.9)
0.008χ
0.417
Serum glucose in µmol/L, mean ± SD†
5.5 (1.9)
4.9 (0.5)
0.074φ
0.245
0.6
0.3
1.4
Serum albumin in g/L, mean ± SD†
36.3 (6.2)
34.7 (7.6)
0.361φ
φMann–Whitney U-test; χchi-square or Fisher's exact test; †preoperative laboratory values. Variables with a (italics) in the univariate analysis were used for multivariable analysis. Significance was set at (marked in bold).
