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Stroke Research and Treatment
Volume 2010 (2010), Article ID 245715, 4 pages
http://dx.doi.org/10.4061/2010/245715
Clinical Study

Clinical Significance of Serum Zinc Levels in Cerebral Ischemia

Division of Cerebrovascular Diseases and Sparrow Hospital William and Claire Dart Stroke Center, A-217 Clinical Center, Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, USA

Received 14 November 2010; Revised 4 December 2010; Accepted 15 December 2010

Academic Editor: Helmuth Steinmetz

Copyright © 2010 Archit Bhatt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Zinc mediates several vital physiological, enzymatic and cellular functions. The association between serum zinc and stroke outcome has not been previously evaluated. Methods. This single center retrospective study was conducted on consecutive stroke ( 𝑛 = 1 5 8 ) and TIA ( 𝑛 = 7 4 ) patients. We sought to determine whether serum zinc concentrations in patients with acute ischemic strokes were associated with stroke severity and poor functional status at discharge, respectively. Results. Overall, out of the 224 patients analyzed (mean age 67 years), 35.7% patients had low zinc levels (65 mcg/dL). Patients with stroke ( 𝑛 = 1 5 2 ) were more likely to have low zinc levels ( O R = 2 . 6 2 , CI 1 . 9 2 - 3 . 5 7 , 𝑃 < . 0 0 3 ) compared to patients with TIA ( 𝑛 = 7 2 ). For patients with stroke ( 𝑛 = 1 5 2 ), multivariate analysis showed that low serum zinc levels (OR 2.82, CI 1 . 3 5 - 5 . 9 1 , 𝑃 = . 0 3 5 ) and strokes with admission severe strokes ( N I H S S > 8 ) (OR 2.68, CI 1 . 1 - 6 . 5 , 𝑃 = . 0 3 ) were independently associated with poor functional status ( M R S > 3 ) at discharge from the hospital. Conclusion. Low serum zinc concentrations are associated with more severe strokes on admission and poor functional status at discharge.