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Stroke Research and Treatment
Volume 2011, Article ID 686797, 4 pages
Review Article

Barriers of Thrombolysis Therapy in Developing Countries

1Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, P.O. Box: 91766-99199, Iran
2Department of Neurology, Ghaem Hospital, Ahmadabad Street, Mashhad, P.O. Box: 91766-99199, Iran

Received 18 December 2010; Revised 31 January 2011; Accepted 13 February 2011

Academic Editor: Bruce Ovbiagele

Copyright © 2011 Kavian Ghandehari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The developing world carries the highest burden of stroke mortality and stroke-related disability. The number of stroke patients receiving r-tPA in the developing world is extremely low. Prehospital delay, financial constraints, and lack of infrastructure are main barriers of thrombolysis therapy in developing countries. Until a cheaper thrombolytic agent and the proper infrastructure for utilization of thrombolytic therapy is available, developing countries should focus on primary and secondary stroke prevention strategies. However, governments and health systems of developing countries should efforts exerb for promotion of their infrastructure of stroke care.