A Comparison of Cooling Techniques to Treat Cardiac Arrest Patients with Hypothermia

Table 1

Baseline characteristics and adverse events during the first week in the endovascular-(𝑁=26) and surface-cooled groups (𝑁=15).

Characteristic/adverse event	Endovascular number (%)	Surface number (%)	P value^a
Baseline characteristic
Mean age (years)	63±17	58±15	.28
Sex (males)	18 (69%)	12 (80%)	.22
Mean weight (kg)	82±21	95±37	.15
Duration of the arrest (min)	31	24	.13
Ventricular fibrillation arrests	12 (46%)	1 (7%)	.008
Median time from arrest to initiation of cooling protocol (min)	277	481	.16
Median Bladder T at initiation of cooling (°C)	36.4	36.4	.76
Renal failure on admission^b	10 (38%)	10 (67%)	.06
Adverse Events
Hypotension^c	10 (38%)	4 (27%)	.21
Bradycardia^d	18 (69%)	8 (53%)	.16
Other arrhythmias	6 (23%)	4 (27%)	.28
New infection in 1st week	16 (62%)	8 (53%)	.23
Pneumonia	14 (54%)	7 (47%)	.23
Sepsis	1 (4%)	0 (0%)	.63
Pancreatitis	0 (0%)	0 (0%)	—
Renal failure 1st week^e	6 (23%)	4 (27%)	.25
Hemodialysis	1 (4%)	1 (7%)^f	.48
Coagulopathy^g	6 (23%)	4 (27%)	.77
Groin hematoma	0 (0%)	N/A	—
Skin injury	0 (0%)	0 (0%)	—
Transfusion pRBC	6 (23%)	4 (27%)	.28
Transfusion of platelets	1 (4%)	0 (0%)	.63
Seizures^h	2 (8%)	2 (13%)	.33
Deep venous thrombosis^i	3 (12%)	1 (7%)	.38
Pulmonary embolism	1 (4%)	0 (0%)	.63

^a𝑃 values calculated from Fisher’s exact test and Wilcoxon rank-sum test; ^bcreatinine ≥1.5 mg/dL; ^cmean arterial pressure <70 mm Hg and requiring pressors; ^dheart rate <60/min; ^erise in creatinine ≥0.5 mg/dL; ^falready on hemodialysis as outpatient; ^gINR >1.5 or PTT > 40 sec within 48 hours of cooling; ^hnot including clinical evidence of status myoclonus.