Research Article
Functional Inflammatory Genotypes in Ischemic Stroke: Could We Use Them to Predict Age of Onset and Long-Term Outcome?
Table 4
Association of inflammatory genotypes with long-term functional outcome of an IS.
| | Genotypes | Logistic regression | | TNF-α-308G>A | Presence of GG | | 6-month outcome | AG | GG | OR* | 95% CI | |
| (BI: 16–20) good (%)
(BI: <16, or death) bad (%) | 15 (17)
13 (25.5) | 73 (83)
38 (74.5) | Referent
0.19 | 0.04–0.86 | .03 |
| | IL6-174G>C | Presence of GC/CC | | GG | GC/CC | OR* | 95% CI | |
| (BI: 16–20) good (%)
(BI: <16, or death) bad (%) | 54 (64.3)
34 (62.8) | 30 (35.7)
21 (38.2) | Referent
1.14 | 0.37–3.54 | .82 |
| | IL12B 1188A>C | Presence of AC | | AA/CC | AC | OR* | 95% CI | |
| (BI: 16–20) good (%)
(BI: <16, or death) bad (%) | 48 (54.5)
37 (72.5) | 40 (45.5)
14 (27.5) | Referent
0.69 | 0.23–2.09 | .52 |
| | IL4-589C>T | Presence of CT | | CC | CT | OR* | 95% CI | |
| (BI: 16–20) good (%)
(BI: <16, or death) bad (%) | 71 (84.1)
43 (84.3) | 14 (15.9)
8 (15.7) | Referent
0.67 | 0.17–2.59 | .56 |
| | IL10-1082G>A | Presence of GG | | GG | AG/AA | OR* | 95% CI | |
| (BI: 16–20) good (%)
(BI: <16, or death) bad (%) | 14 (15.9)
12 (23.5) | 74 (84.1)
39 (76.5) | Referent
2.65 | 0.57–12.40 | .22 |
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BI: barthel index, OR: odds ratio, CI: confidence intervals.
*ORs adjusted for age, sex, hypertension, diabetes, hyperlipidemia, ischemic heart disease, smoking, stroke severity on admission and TOAST categories.
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