Research Article

Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats

Figure 2

Glib attenuates hemispheric swelling in a rat model of pMCAO. The extent of swelling was calculated using the equation: Extent of edema = (volume of ipsilateral hemisphere  − volume of contralateral hemisphere)/volume of contralateral hemisphere. Treatment with Glib significantly decreased hemispheric swelling compared to the vehicle-treated group at 48 h. P < 0.05; *significant difference compared to MCAO + Vehicle. Values are expressed as mean ± SE.
460909.fig.002