Clinical Trials in Cardiac Arrest and Subarachnoid Hemorrhage: Lessons from the Past and Ideas for the Future

Table 5

Number of randomized, controlled trials published and ongoing for aneurysmal subarachnoid hemorrhage and cardiac arrest.

Intervention	SAH		Cardiac arrest
	Published; 𝑁 (%)	Ongoing; 𝑁 (%)	Published; 𝑁 (%)	Ongoing; 𝑁 (%)
Calcium channel blockers	10 (18)	0	4 (9)	0
Antifibrinolytics	5 (9)	0	0	0
Neuroprotective drugs	5 (9)	2 (8)	1 (2)	1 (7)
Statins	4 (7)	5 (20)	0	0
Aneurysm clip or coil	4 (7)	1 (4)	NA	NA
Lipid peroxidation inhibitor	4 (7)	1 (4)	0	0
Thrombolytics	3 (5)	1 (4)	2 (4)	0
Antiplatelets	3 (5)	0	0	0
Steroids	3 (5)	0	1 (2)	0
Transfusion/blood products/erythropoietin	3 (5)	1 (4)	0	0
Vasodilators	3 (5)	4 (16)	0	0
Pressors or HHH	2 (4)	2 (8)	9 (19.5)	0
Magnesium	2 (4)	0	5 (11)	1 (7)
Rho-kinase inhibitor (fasudil)	2 (4)	0	0	0
Adrenergic blockade	1 (2)	0	0	0
Endovascular therapy	1 (2)	0	NA	NA
Insulin/glucose control	1 (2)	0	2 (4)	0
Hypothermia	1 (2)	0	5 (11)	9 (64)
CSF diversion	0	2 (8)	0	0
Antiepileptics	0	2 (8)	0	0
Sedation	0	1 (4)	0	0
Rehabilitation	0	1 (4)	0	0
Blood pressure	0	1 (4)	0	0
Other	0	1 (4)	0	0
Chest compressions	NA	NA	7 (15)	2 (14)
Adenosine antagonist	0	0	1 (2)	0
Fluid management	0	0	1 (2)	0
Barbiturate	0	0	1 (2)	0
Cerebral oxygenation	0	0	0	1 (7)
Calcium chloride	0	0	3 (7)	0
Sodium bicarbonate	0	0	2 (4)	0
Hemofiltration	0	0	1 (2)	0
Rhythm analysis	0	0	1 (2)	0
Total	57	25	46	14