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Stroke Research and Treatment
Volume 2013, Article ID 424769, 4 pages
Research Article

Frontal Lobe Atrophy in Depression after Stroke

1Department of Psychiatry, Chinese University of Hong Kong, Hong Kong
2Department of Psychiatry, Shatin Hospital, Hong Kong
3Department of Neurology, Dongguan People's Hospital, Dongguan, Guangdong, China
4Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong
5Department of Imaging & Interventional Radiology, Chinese University of Hong Kong, Hong Kong
6School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Western Australia, Australia
7University of Notre Dame Australia/Marian Centre, Perth, Western Australia, Australia

Received 27 June 2012; Accepted 21 January 2013

Academic Editor: Helmuth Steinmetz

Copyright © 2013 W. K. Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Frontal lobe atrophy (FLA) is associated with late life depression. However, the role that FLA plays in the development of depression after stroke (DAS) remains unknown. This study thus examined the association between FLA and DAS. Methods. A convenience sample of 705 Chinese patients with acute ischemic stroke admitted to the acute stroke unit of a university-affiliated regional hospital in Hong Kong participated in the study. A psychiatrist administered the Structural Clinical Interview for DSM-IV to all patients and made a diagnosis of DAS three months after the index stroke. Results. Eighty-five (12.1%) patients were diagnosed with DAS. In univariate analysis, the DAS patients were more likely to have severe FLA (14.1% versus 5.6%). Severe FLA remained an independent predictor of DAS in multivariate analysis, with an odds ratio of 2.6 (95% confidence intervals = 1.2–5.9). Conclusions. The results suggest that FLA may play a role in the pathogenesis of DAS, which supports the hypothesis that cumulative vascular burden may be important in predicting DAS. Further investigations are needed to clarify the impact of FLA on the clinical presentation, treatment response, and outcome of DAS in stroke survivors.