Influence of Medication on Fatigue Six Months after Stroke
Table 2
Medication use at discharge and 6 months after stroke onset overall and according to 6-month poststroke fatigue.
Overall ()
Poststroke fatigue
value
OR (95% CI)
value
No ()
Yes ()
Discharge treatment
Statin
110 (71.9)
49 (68.1)
61 (75.3)
0.32
1.66 (0.74–3.73)
0.22
Beta-blocker
51 (32.7)
20 (27.8)
30 (37.0)
0.22
1.39 (0.63–3.06)
0.42
Anxiolytic
16 (10.5)
5 (6.9)
11 (13.6)
0.18
1.41 (0.42–4.75)
0.58
Hypnotic
21 (13.7)
8 (11.1)
13 (16.1)
0.38
0.78 (0.25–2.45)
0.68
Antidepressant
20 (13.1)
5 (6.9)
15 (18.5)
0.034
2.13 (0.65–6.98)
0.21
Antihypertensive
110 (71.9)
51 (70.8)
59 (72.8)
0.78
1.17 (0.53–2.58)
0.70
Antidiabetes medications
17 (11.1)
5 (6.9)
12 (14.8)
0.12
1.64 (0.52–5.10)
0.40
Antiplatelet drug
122 (79.7)
59 (81.9)
63 (77.8)
0.52
1.09 (0.44–2.71)
0.85
Anticoagulant
36 (23.6)
16 (22.2)
20 (24.7)
0.72
0.93 (0.39–2.21)
0.86
Number of treatments, median (IQR)
3 (2–4)
3 (2-3)
3 (2–4)
0.024
1.30 (0.92–1.83)
0.14
6-month treatment
Statin
116 (75.8)
53 (73.6)
63 (77.8)
0.55
1.89 (0.80–4.46)
0.15
Beta-blocker
51 (33.3)
19 (26.4)
32 (39.5)
0.086
1.73 (0.80–3.71)
0.16
Anxiolytic
20 (13.1)
8 (11.1)
12 (14.8)
0.50
0.75 (0.25–2.23)
0.61
Hypnotic
17 (11.1)
8 (11.1)
9 (11.1)
1.00
0.67 (0.20–2.20)
0.51
Antidepressant
26 (17.0)
6 (8.3)
20 (24.7)
0.007
2.08 (0.70–6.14)
0.18
Antihypertensive
124 (81.1)
55 (76.4)
69 (85.2)
0.17
1.92 (0.77–4.78)
0.16
Antidiabetes medications
18 (11.8)
6 (8.3)
12 (14.8)
0.21
1.64 (0.52–5.10)
0.40
Antiplatelet drug
105 (68.6)
51 (70.8)
54 (66.7)
0.58
1.21 (0.54–2.70)
0.64
Anticoagulant
50 (32.7)
21 (29.2)
29 (35.8)
0.38
0.95 (0.42–2.12)
0.90
Number of treatments, median (IQR)
3 (3-4)
3 (2–4)
3 (3-4)
0.020
1.34 (0.94–1.91)
0.11
Values are expressed as number (%) unless otherwise indicated. Calculated using logistic regression model adjusted for gender, coronary heart disease history, 6-month Barthel Index score, depression, anxiety, and sleep disturbances (after multiple imputation to handle missing values on covariate).
