Research Article
Thrombin Generation in Acute Ischaemic Stroke
Table 5
Haemostatic activation after rtPA therapy.
| Category | No rtPA time 1 () time 2 () | rtPA time 1 () time 2 () | p value |
| Thrombin generation assays | | | | Lag time 1 (min)-median (IQR) | 3.3 (3.0, 4.1) | 3.3 (3.0, 4.0) | 0.60 | Lag time 2 (min)-median (IQR) | 3.6 (2.9, 4.3) | 3.3 (3.2, 4.0) | 0.30 | Median difference, 95% CI | 0.30 (−0.70–0.10) | 0.00 (−0.51–0.51) | | ETP 1 (nm min)-mean (SD) | | | 0.37 | ETP 2 (nm min)-mean (SD) | | | 0.65 | Mean difference, 95% CI | 48.0 (−49.75–145.75) | 137 (−12.98–286.98) | | ttP 1 (min)- median (IQR) | 5.9 (5.3, 6.8) | 6.0 (5.2, 6.9) | 0.68 | ttP2 (min)-median (IQR) | 6.2 (5.6, 7.2) | 5.9 (5.2, 6.6) | 0.20 | Median difference, 95% CI | −0.30 (−0.70–0.10) | 0.10 (−0.41–0.61) | | Peak 1 (nm)-mean (SD) | | | 0.64 | Peak 2 (nm)-mean (SD) | | | 0.99 | Mean difference, 95% CI | 1.00 (−20.96–22.96) | −5.00 (−31.28–21.28) | | Standard coagulation assays | | | | D-dimer 1 (ng/mL)-median (IQR) | 1155 (580, 2145) | 1670 (650, 3890) | 0.07 | D-dimer 2 (ng/mL)-median (IQR) | 1100 (650, 2770) | 1415 (480, 3050) | 0.98 | Median difference, 95% CI | 55.0 (−127.59–237.59) | 255.0 (39.08–470.92) | | Fibrinogen 1 (g/L)- mean (SD) | | | 0.006 | Fibrinogen 2 (g/L)-mean (SD) | | | 0.08
| Mean difference, 95% CI | −0.60 (−0.99–−0.21) | −0.9 (−1.41–−0.39) | |
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