Stroke Research and Treatment / 2016 / Article / Tab 5

Research Article

Thrombin Generation in Acute Ischaemic Stroke

Table 5

Haemostatic activation after rtPA therapy.

CategoryNo rtPA
time 1 ()
time 2 ()
rtPA
time 1 ()
time 2 ()
p value

Thrombin generation assays
Lag time 1 (min)-median (IQR)3.3 (3.0, 4.1)3.3 (3.0, 4.0)0.60
Lag time 2 (min)-median (IQR)3.6 (2.9, 4.3)3.3 (3.2, 4.0)0.30
 Median difference, 95% CI 0.30 (−0.70–0.10)0.00 (−0.51–0.51)
ETP 1 (nm min)-mean (SD)0.37
ETP 2 (nm min)-mean (SD)0.65
 Mean difference, 95% CI48.0 (−49.75–145.75)137 (−12.98–286.98)
ttP 1 (min)- median (IQR)5.9 (5.3, 6.8)6.0 (5.2, 6.9)0.68
ttP2 (min)-median (IQR)6.2 (5.6, 7.2)5.9 (5.2, 6.6)0.20
 Median difference, 95% CI−0.30 (−0.70–0.10)0.10 (−0.41–0.61)
Peak 1 (nm)-mean (SD)0.64
Peak 2 (nm)-mean (SD)0.99
 Mean difference, 95% CI1.00 (−20.96–22.96)−5.00 (−31.28–21.28)
Standard coagulation assays
D-dimer 1 (ng/mL)-median (IQR)1155 (580, 2145)1670 (650, 3890)0.07
D-dimer 2 (ng/mL)-median (IQR)1100 (650, 2770)1415 (480, 3050)0.98
 Median difference, 95% CI55.0 (−127.59–237.59)255.0 (39.08–470.92)
Fibrinogen 1 (g/L)- mean (SD)0.006
Fibrinogen 2 (g/L)-mean (SD)0.08
 Mean difference, 95% CI−0.60 (−0.99–−0.21)−0.9 (−1.41–−0.39)

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