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Stroke Research and Treatment
Volume 2016, Article ID 9706720, 12 pages
http://dx.doi.org/10.1155/2016/9706720
Research Article

Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials

1Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham NG5 1PB, UK
2Neurological & Mental Health Division, University of Sydney, Sydney, NSW 2000, Australia
3Department of Internal Medicine, Oslo University Hospital, 0424 Oslo, Norway
4Oxford Academic Health Sciences Network, Oxford University Hospitals, NHS Trust, Oxford OX4 4GA, UK
5Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Disease, University of Leicester, Leicester LE3 9QP, UK
6Geffen School of Medicine at UCLA, UCLA Comprehensive Stroke Center, Los Angeles, CA 90095, USA
7Division of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK
8University of Nottingham, Nottingham NG5 1PB, UK

Received 20 November 2015; Accepted 14 January 2016

Academic Editor: David Vaudry

Copyright © 2016 Philip M. Bath et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary material contains information on the study investigators and includes further data from this systematic review. Supplemental Table 1 contains the characteristics of the trials which were included in this systematic review. Supplemental Table 2 contains the baseline characteristics of enrolled patients from all five studies by time to randomisation. Supplemental Figure 1 contains a flow diagram of the search for eligible trials. Supplemental Figure 2 contains a forest plot of a subgroup analysis of the modified Rankin scale (mRS) at 90 days, for patients randomised within 6 hours of stroke onset. Supplemental Figure 3 contains a shift diagram on the mRS at day 90 in patients with intracerebral haemorrhage who were randomised within 6 hours of stroke onset. Supplemental Figure 4 contains a shift diagram of the mRS at day 90 in patients with ischaemic stroke who were randomised within 6 hours of stroke onset. Supplemental Figure 5 contains a shift diagram of the mRS at 90 days in patients with ischaemic stroke who received alteplase and who were randomised within 6 hours of stroke onset. Supplemental Figure 6 contains a shift diagram of the mRS at 90 days in patients with ischaemic stroke who did not receive alteplase and who were randomised within 6 hours of stroke onset.

  1. Supplementary Material