Table of Contents Author Guidelines Submit a Manuscript
Stroke Research and Treatment
Volume 2017 (2017), Article ID 1935136, 9 pages
https://doi.org/10.1155/2017/1935136
Research Article

Serum Uric Acid Is Associated with Poor Outcome in Black Africans in the Acute Phase of Stroke

1Department of Clinical Sciences, University of Douala, Douala, Cameroon
2Department of Internal Medicine, Douala General Hospital, Douala, Cameroon
3Department of Internal Medicine, University of Yaoundé I, Douala, Cameroon

Correspondence should be addressed to Yacouba N. Mapoure

Received 17 June 2017; Revised 16 July 2017; Accepted 24 July 2017; Published 10 September 2017

Academic Editor: David S. Liebeskind

Copyright © 2017 Yacouba N. Mapoure et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Prognostic significance of serum uric acid (SUA) in acute stroke still remains controversial. Objectives. To determine the prevalence of hyperuricemia and its association with outcome of stroke patients in the Douala General Hospital (DGH). Methods. This was a hospital based prospective cohort study which included acute stroke patients with baseline SUA levels and 3-month poststroke follow-up data. Associations between high SUA levels and stroke outcomes were analyzed using multiple logistic regression and survival analysis (Cox regression and Kaplan-Meier). Results. A total of 701 acute stroke patients were included and the prevalence of hyperuricemia was 46.6% with a mean SUA level of 68.625 ± 24 mg/l. Elevated SUA after stroke was associated with death (OR = 2.067; 95% CI: 1.449–2.950; p < 0.001) but did not predict this issue. However, an independent association between increasing SUA concentration and mortality was noted in a Cox proportional hazards regression model (adjusted HR = 1.740; 95% CI: 1.305–2.320; p < 0.001). Furthermore, hyperuricemia was an independent predictor of poor functional outcome within 3 months after stroke (OR = 2.482; 95% CI: 1.399–4.404; p = 0.002). Conclusion. The prevalence of hyperuricemia in black African stroke patients is quite high and still remains a predictor of poor outcome.